360: DEPRESSIONS Biological Roots: Vagus Nerve, Gut Health & Incretin Hormones/Peptides - GLP1 GLP2 & GIP

360: DEPRESSIONS Biological Roots: Vagus Nerve, Gut Health & Incretin Hormones/Peptides - GLP1 GLP2 & GIP

Author: The Natural Alternative - with Madonna Guy ND May 18, 2026 Duration: 6:04

madonnaguy.myorygn.co 

As a naturopath and kinesiologist with over 30 years of clinical experience, I’ve seen firsthand how chronic depression, trauma, and long-term stress create deep biological changes that most treatments simply don’t address. In the video, I explained how the vagus nerve, gut integrity, inflammation, metabolic regulation, and stress hormones all interact as one interconnected system. When someone has lived through early-life trauma or persistent stress, this entire circuit becomes dysregulated — and no amount of “positive thinking” can override biology that’s been pushed into survival mode for years. This is why so many people feel like they’ve “tried everything” yet still struggle.

I also introduced the concept of Tri‑GLP, which supports the GLP‑1, GLP‑2, and GIP pathways simultaneously. These pathways regulate appetite, blood sugar, inflammation, gut repair, and even aspects of mood and nervous system function. While bitter receptors can stimulate GLP‑1 release, Tri‑GLP works downstream to support the deeper metabolic, gut, and neuroimmune repair that trauma and chronic stress disrupt. For many people, this triple-pathway support may be the missing biological piece that helps their system finally shift out of survival mode and into healing.

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Madonna Guy brings a thoughtful and grounded perspective to the often noisy world of wellness in The Natural Alternative. As a practicing naturopath, she sits down with a diverse range of experts-from scientists and researchers to seasoned practitioners in various fields-to explore the practical intersections of traditional wisdom and modern evidence. This isn't about quick fixes or extreme ideologies; instead, each conversation unfolds like a deep dive into how our bodies and minds truly work. You'll hear discussions that thoughtfully examine nutrition, mental well-being, sustainable fitness, and the science behind holistic practices, all aimed at empowering informed choices. The tone is curious and conversational, making complex topics accessible without oversimplifying them. Tune into this podcast for a refreshingly balanced take on health, where the goal is building a resilient and vibrant life through understanding, not dogma. Madonna's approach makes The Natural Alternative a trusted space for anyone looking to move beyond the headlines and cultivate a personal sense of vitality.
Author: Language: English Episodes: 100

The Natural Alternative - with Madonna Guy
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