361: pHix Bitter Extracts vs Tri‑GLP: Two Pathways, One Goal — Better Metabolism & Gut‑Brain Balance

361: pHix Bitter Extracts vs Tri‑GLP: Two Pathways, One Goal — Better Metabolism & Gut‑Brain Balance

Author: The Natural Alternative - with Madonna Guy ND May 18, 2026 Duration: 5:24

TriGLP - madonnaguy.myorygn.co

From my clinical perspective, pHix matured hops bitter extracts and Tri‑GLP work on the same metabolic–gut–brain network, but they do so through very different mechanisms. pHix activates T2R bitter receptors in the gut, triggering natural GLP‑1 release and supporting appetite regulation, digestion, and vagal signaling. Tri‑GLP, on the other hand, works downstream by directly activating GLP‑1, GLP‑2, and GIP receptors simultaneously, offering deeper support for gut barrier repair, inflammation reduction, metabolic flexibility, and nervous‑system regulation. While bitter extracts stimulate the body’s own incretin response, Tri‑GLP provides a more comprehensive triple‑pathway activation — and together, they converge on the same biological circuitry disrupted by chronic stress, trauma, and long‑term metabolic imbalance.

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Madonna Guy brings a thoughtful and grounded perspective to the often noisy world of wellness in The Natural Alternative. As a practicing naturopath, she sits down with a diverse range of experts-from scientists and researchers to seasoned practitioners in various fields-to explore the practical intersections of traditional wisdom and modern evidence. This isn't about quick fixes or extreme ideologies; instead, each conversation unfolds like a deep dive into how our bodies and minds truly work. You'll hear discussions that thoughtfully examine nutrition, mental well-being, sustainable fitness, and the science behind holistic practices, all aimed at empowering informed choices. The tone is curious and conversational, making complex topics accessible without oversimplifying them. Tune into this podcast for a refreshingly balanced take on health, where the goal is building a resilient and vibrant life through understanding, not dogma. Madonna's approach makes The Natural Alternative a trusted space for anyone looking to move beyond the headlines and cultivate a personal sense of vitality.
Author: Language: English Episodes: 100

The Natural Alternative - with Madonna Guy
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