404: How Chronic Stress Rewires the Amygdala, Hippocampus, Prefrontal Cortex and BNST Over Time

404: How Chronic Stress Rewires the Amygdala, Hippocampus, Prefrontal Cortex and BNST Over Time

Author: The Natural Alternative - with Madonna Guy ND July 21, 2026 Duration: 48:43

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Chronic stress and unresolved trauma don’t just “affect” the brain — they physically reshape it. The amygdala becomes hyper‑reactive and enlarged, priming the body to scan for danger even in safe environments. The hippocampus, responsible for memory and learning, shrinks under long‑term cortisol exposure, making it harder to store new memories and easier to relive old ones as if they’re happening now. The prefrontal cortex — our centre for logic, planning, emotional regulation and decision‑making — goes offline when stress is high, which is why people feel impulsive, overwhelmed, foggy, or unable to “think straight.” And the BNST (bed nucleus of the stria terminalis), the region responsible for sustained anxiety and anticipatory fear, becomes overactive when emotions are suppressed or avoided. Together, these changes create a brain that is wired for survival rather than connection, creativity, or calm.

#Amygdala #Hippocampus #PrefrontalCortex #BNST #ChronicStress #TraumaHealing #Neuroplasticity #BrainHealth #NervousSystemRegulation #VagusNerve #EmotionalProcessing #SomaticHealing #Kinesiology #Counselling #HolisticTherapy #StressRecovery #MentalResilience #MindBodyConnection #Neurobiology #TraumaInformedCare #NewLeafNaturalTherapies #MadonnaGuy #DavidSheil #BrisbaneNaturopath #YouAreNotBroken #WholeBodyHealing


Madonna Guy brings a thoughtful and grounded perspective to the often noisy world of wellness in The Natural Alternative. As a practicing naturopath, she sits down with a diverse range of experts-from scientists and researchers to seasoned practitioners in various fields-to explore the practical intersections of traditional wisdom and modern evidence. This isn't about quick fixes or extreme ideologies; instead, each conversation unfolds like a deep dive into how our bodies and minds truly work. You'll hear discussions that thoughtfully examine nutrition, mental well-being, sustainable fitness, and the science behind holistic practices, all aimed at empowering informed choices. The tone is curious and conversational, making complex topics accessible without oversimplifying them. Tune into this podcast for a refreshingly balanced take on health, where the goal is building a resilient and vibrant life through understanding, not dogma. Madonna's approach makes The Natural Alternative a trusted space for anyone looking to move beyond the headlines and cultivate a personal sense of vitality.
Author: Language: English Episodes: 50

The Natural Alternative - with Madonna Guy
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