Jason predicts a “major M&A moment” in the next six months! | E2213

Jason predicts a “major M&A moment” in the next six months! | E2213

Author: Jason Calacanis November 22, 2025 Duration: 55:35

Register here to join Founder University Japan’s kickoff: https://luma.com/cm0x90mk


Today’s show:

Google and Meta had their cases dismissed (or received a slap on the wrist)… Despite all the backlash and cynicism, AI companies continue making bank and releasing hot new products… What does it all mean?

For Jason Calacanis, the signs are pointing to a “major M&A moment,” with huge opportunities for increased efficiency and consolidation among America’s favorite brands and largest companies?

Who will it be? Join Jason and Alex for a round of hot speculation.

PLUS why Jason thinks Michael Burry is both right and wrong about GPU depreciation, why NOTHING is certain about these OpenAI mega-deals, Google’s Nano Banana Pro can make infographics and they’re VERY impressive… and much more.

Timestamps:

(1:54) Jason’s calling in from Vegas… He’s doing a hot lap at F1!

(3:18) How restaurants are becoming the new Hot IP

(6:50) Founder University is heading to TOKYO!

(9:27) Why Jason thinks the future of startups is truly global

(10:06) Pipedrive - Bring your entire sales process into one elegant space. Get started with a 30 day free trial at pipedrive.com/twist

(11:39) Nvidia killed it on the numbers… but what are the vibes around AI? Jason sounds off.

(13:05) Why nothing is certain when it comes to the Nvidia/OpenAI deal

(19:40) Is Google now WINNING consumer adoption of AI? How did it get this close?

(19:57) Crusoe Cloud: Crusoe is the AI factory company. Reliable infrastructure and expert support. Visit https://crusoe.ai/build to reserve your capacity for the latest GPUs today.

(26:07) Meanwhile, AI apps are still dominating the iOS Store

(27:09) Why Jason and Alex think Michael Burry’s both right and wrong about GPU depreciation

(30:13) Northwest Registered Agent - Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!

(37:46) We’re testing out Nano Banana Pro on a BBQ infographic challenge

(43:42) What a week for AI models! It doesn’t seem like things are slowing down…

(46:12) Kalshi is growing fast, but can it catch Polymarket?

(47:50) Is a rate cut coming? Jason and Alex read the tea leaves.

(50:13) Why Jason predicts a “major M&A moment” in the next six months

(52:09) VIEWER QUESTION: What should a software engineer be working on RIGHT NOW.

(54:02) Founder Friday is now… STARTUP SUPPER CLUB


Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

Check out the TWIST500: https://www.twist500.com

Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp


Follow Lon:

X: https://x.com/lons


Follow Alex:

X: https://x.com/alex

LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm


Follow Jason:

X: https://twitter.com/Jason

LinkedIn: https://www.linkedin.com/in/jasoncalacanis


Thank you to our partners:

(10:06) Pipedrive - Bring your entire sales process into one elegant space. Get started with a 30 day free trial at pipedrive.com/twist

(19:57) Crusoe Cloud: Crusoe is the AI factory company. Reliable infrastructure and expert support. Visit https://crusoe.ai/build to reserve your capacity for the latest GPUs today.

(30:13) Northwest Registered Agent - Form your entire business identity in just 10 clicks and 10 minutes. Get more privacy, more options, and more done—visit https://www.northwestregisteredagent.com/twist today!


Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland


Check out Jason’s suite of newsletters: https://substack.com/@calacanis


Follow TWiST:

Twitter: https://twitter.com/TWiStartups

YouTube: https://www.youtube.com/thisweekin

Instagram: https://www.instagram.com/thisweekinstartups

TikTok: https://www.tiktok.com/@thisweekinstartups

Substack: https://twistartups.substack.com


Every week, Jason Calacanis dives headfirst into the swirling vortex of Silicon Valley and global tech with This Week in Startups. It’s a direct line to the conversations shaping our digital future, moving far beyond surface-level news. You’ll hear Jason’s unfiltered analysis on everything from market shifts and media trends to the underlying mechanics of building a business, all delivered with a blend of enthusiasm and seasoned skepticism. The core of this podcast, however, lies in the guests. Jason sits down with the very people driving change-founders who have scaled impossible heights, operators managing daily chaos, and investors who spot trends before they become obvious. These conversations are less like formal interviews and more like insider debriefs, pulling back the curtain on real strategies, painful failures, and unexpected successes. For anyone curious about how technology is built, funded, and ultimately changes the world, this series offers a front-row seat. It’s the context behind the headlines, providing a deeper understanding of the forces at play in startups and technology. Tune in for a consistently engaging and insightful look at the ecosystem, straight from someone who lives and breathes it.
Author: Language: en-us Episodes: 100

This Week in Startups
Podcast Episodes
Jason’s Top CES Products and Takeaways | E2232 [not-audio_url] [/not-audio_url]

Duration: 1:09:08
This Week In Startups is made possible by:Hubspot - http://clickhubspot.com/twist1Circle.so - http://circle.so/twistSentry - http://sentry.io/twistToday’s show: On the last TWiST episode before Jason goes to Japan and Al…
Jason’s ultimate dream mega-purchase + Founder Q’s | E2228 [not-audio_url] [/not-audio_url]

Duration: 45:03
This Week In Startups is made possible by:Northwest Registered Agent- https://www.northwestregisteredagent.com/twistVanta - http://www.vanta.com/twistLemon IO - https://lemon.io/twistToday’s show: Jason’s already a milli…
Waymo Madness in SF! Why robotaxis clogged the streets | E2227 [not-audio_url] [/not-audio_url]

Duration: 59:35
This Week In Startups is made possible by:Caldera + Lab - http://calderalab.com/TWISTCrusoe Cloud - https://crusoe.ai/buildUber - http://uber.com/twistToday’s show: Why did a power outage in the Bay Area cause Waymos to…
Level up your copywriting w/ Sam Parr | E2226 [not-audio_url] [/not-audio_url]

Duration: 1:06:13
This Week In Startups is made possible by:Luma AI - https://lumalabs.ai/twistNorthwest Registered Agent - https://www.northwestregisteredagent.com/twist Lemon IO - https://lemon.io/twistToday’s show: DID YOU KNOW… most o…
Is this the end for the Roomba? Why iRobot went bankrupt | E2224 [not-audio_url] [/not-audio_url]

Duration: 1:00:42
This Week In Startups is made possible by:Vanta - https://www.vanta.com/twistNetSuite - https://www.netsuite.com/twistLemon.io - https://lemon.io/twist*Today’s show: Domestic robots have never been hotter… so why is iRob…