The 5-Step Framework for AI Agents That Improve While You Sleep | E2269

The 5-Step Framework for AI Agents That Improve While You Sleep | E2269

Author: Jason Calacanis March 31, 2026 Duration: 1:27:14

This Week In Startups is made possible by:

Quo - https://quo.com/TWiST

LinkedIn Jobs - https://LinkedIn.com/twist

Iru - https://iru.com/twist

Plaud - https://Plaud.ai/twist


Today’s show:


Google project manager Shubham Saboo is running 6 AI agents on a Mac Mini that handle all of his side business autonomously, from research, to social posts, to newsletters.

He joins Jason and Lon to walk us through his 5-step framework for designing an efficient AI agent team:

  • Start with one agent and onboard them like a new hire

  • Stop Googling fixes; just ask your agent how to use it

  • Put your agents on fixed schedules

  • Add shared memory so you don’t have to repeat yourself

  • Let agents run self-reviews and rewrite their own instructions.

Get the walkthrough to put this entire plan into practice on today’s episode. PLUS fresh demos of the “Minecraft”-inspired virtual workspace MoltWorld and AgentMail, which is Gmail for your AI pals, and Jason explains the thinking behind his viral, controversy-stirring “don’t talk to journalists” tweet.

Follow Shubham: https://x.com/Saboo_Shubham_

“How I Built an Autonomous AI Agent Team That Runs 24/7” on X: https://x.com/Saboo_Shubham_/status/2022014147450614038?s=20

Follow Mike: https://x.com/mihalich1988

MoltWorld: https://moltworld.io/

Follow Haakam: https://x.com/haakamaujla

AgentMail: https://www.agentmail.to/

Jason’s post about talking to journalists: https://x.com/Jason/status/2037573025458016659

NYT responds: https://x.com/NYTimesPR/status/2037648223771263082

Translated Japanese tweets: https://x.com/melonneet40/status/2038020624015315289, https://x.com/rambling_28/status/2038041455999246422

Japanese people singing “Country Roads”: https://x.com/harukaawake/status/2038081269830222259

Trailer for “Nuremberg” (now on Netflix in the US): https://www.youtube.com/watch?v=WvAy9C-bipY

Timestamps:

0:00 Intro

1:24 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!

3:05 We're Claw-pilled once again; it's an all AI Agent showcase

6:15 Google AI PM Shubham Saboo's Top 5 OpenClaw tips

10:14 Quo (formerly OpenPhone) gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at https://quo.com/TWiST.

13:26 Tip #1 — Onboard your agent like a new hire

17:31 Tip #2 — Talk to your agents constantly

19:02 Tip #3 — Put your agents on a schedule

19:51 LinkedIn Jobs - Hire right, the first time. Post your first job and get $100 off towards your job post at https://LinkedIn.com/twist.

23:41 Tip #4 — Add cross-agent memory

29:33 Tip #5 — Let your agents self-improve

29:51 Iru unifies identity, endpoint security, and compliance into one platform. TWiST listeners get 20% off when they book a demo at https://iru.com/twist!

34:03 Why Jason says founders should avoid journalists

38:24 How biased IS the New York Times?

47:02 DEMO: Co-founder Mike Nosov shows us MoltWorld

51:14 But what's the utility of this?

1:05:15 DEMO: Haakam Aujla presents AgentMail (YC S25)

1:09:59 How does AgentMail make money?

1:17:03 How Grok Translations are creating cross-cultural dialogue on X

Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

Check out the TWIST500: https://www.twist500.com

Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp

Follow Lon:

X: https://x.com/lons

Follow Alex:

X: https://x.com/alex

LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm

Follow Jason:

X: https://twitter.com/Jason

LinkedIn: https://www.linkedin.com/in/jasoncalacanis

Check out all our partner offers: https://partners.launch.co/

Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

Check out Jason’s suite of newsletters: https://substack.com/@calacanis




Every week, Jason Calacanis dives headfirst into the swirling vortex of Silicon Valley and global tech with This Week in Startups. It’s a direct line to the conversations shaping our digital future, moving far beyond surface-level news. You’ll hear Jason’s unfiltered analysis on everything from market shifts and media trends to the underlying mechanics of building a business, all delivered with a blend of enthusiasm and seasoned skepticism. The core of this podcast, however, lies in the guests. Jason sits down with the very people driving change-founders who have scaled impossible heights, operators managing daily chaos, and investors who spot trends before they become obvious. These conversations are less like formal interviews and more like insider debriefs, pulling back the curtain on real strategies, painful failures, and unexpected successes. For anyone curious about how technology is built, funded, and ultimately changes the world, this series offers a front-row seat. It’s the context behind the headlines, providing a deeper understanding of the forces at play in startups and technology. Tune in for a consistently engaging and insightful look at the ecosystem, straight from someone who lives and breathes it.
Author: Language: en-us Episodes: 100

This Week in Startups
Podcast Episodes
One Genius Rule That Made This Coffee Brand Famous | EP 2262 [not-audio_url] [/not-audio_url]

Duration: 1:30:27
Legendary British ad man Rory Sutherland invented a fake business on a podcast, a coffee shop appealing to the busy commuter called “Flat White or F**k Off.”But it’s one thing to have a post go big on TikTok or Instagram…
The Global Expansion of Self-Driving Vehicles [not-audio_url] [/not-audio_url]

Duration: 1:09:18
This Week In Startups is made possible by:Circle - http://circle.so/twistSentry - http://Sentry.ioDeel - http://deel.com/twistPlaud - http://Plaud.ai/twistToday’s show:It’s self-driving time! We’re going deep on one of t…
How agents will change banking forever | E2260 [not-audio_url] [/not-audio_url]

Duration: 1:00:38
This Week In Startups is made possible by:Northwest Registered Agent - ⁠⁠northwestregisteredagent.com/twist⁠⁠Quo - ⁠⁠quo.com/TWiST⁠⁠Gusto - ⁠⁠Gusto.com/twist⁠⁠Plaud - http://Plaud.ai/twistAthena - https://www.athena.com/…
Wisdom of the $TAO: the future is decentralized AI [not-audio_url] [/not-audio_url]

Duration: 1:08:26
This Week In Startups is made possible by:Every Banking - https://Every.iohttps://Lemon.io - Lemon.io/twistWispr Flow - https://wisprflow.ai/twistPlaud - https://plaud.ai/twistRo.co - https://Ro.co/TwistToday’s show:*Sur…
Is Anthropic Making the Biggest Mistake in AI History | E2258 [not-audio_url] [/not-audio_url]

Duration: 1:20:55
This Week In Startups is made possible by:Plaud - Plaud.ai/twistLinkedIn Jobs - https://LinkedIn.com/twist.Deel - https://deel.com/twistIru - https://iru.com/twist!Today’s show:It’s a packed TWiST Today! WITH US, we’ve g…
The Biggest Private Funding Round in History | E2256 [not-audio_url] [/not-audio_url]

Duration: 1:20:17
This Week In Startups is made possible by:Deel - http://deel.com/twistWispr Flow - https://wisprflow.ai/twistLuma AI - https://lumalabs.ai/twistToday’s show:*$110 billion buys you 15% of OpenAI. Amazon, Nvidia, and SoftB…
Behind the Scenes with an early OpenClaw contributor! | E2252 [not-audio_url] [/not-audio_url]

Duration: 1:22:11
This Week In Startups is made possible by:Lemon IO - https://Lemon.io/twistEvery.io - https://every.io Sentry.io- https://sentry.io/twistToday’s show:We’re going behind the curtain today — it’s a packed show!We found Tyl…
We Asked 3 Experts How to Get More Value out of OpenClaw | E2253 [not-audio_url] [/not-audio_url]

Duration: 1:08:36
This Week In Startups is made possible by:Gusto - https://Gusto.com/twistCircle - https://circle.so/twistNorthwest Registered Agent - https://northwestregisteredagent.com/twistToday’s show:*Getting OpenClaw set up and ru…