This Bittensor Subnet Could Cut Drug Discovery Costs in HALF | E2267

This Bittensor Subnet Could Cut Drug Discovery Costs in HALF | E2267

Author: Jason Calacanis March 26, 2026 Duration: 1:12:53

This Week In Startups is made possible by:

Luma AI - https://lumalabs.ai/twist

Every.io -  https://every.io

Lemon.io - https://Lemon.io/twistPlaud - https://Plaud.ai/twist

Today’s show:

What do drug discovery, the creator economy, and AI vision models have in common? In the case of Metanova, Bitcast, and Score, the answer is Bittensor. Yes, each of the three companies leverages the Bittensor network to get more work done, more quickly, in a completely decentralized fashion.

Metanova uses its subnet to run developer competitions to find exciting molecular candidates, parsing through a mountain of possibilities to pluck out the most promising for further investigation.

Bitcast uses its subnet to collect visibility demand from brands, which is served by video creators. The company is focused on the crypto niche to start, but will expand in time to other technology topics.

Score uses its subnet to generate highly performant, specialized vision models, which it then sells to customers through a platform (Manako).

In each case, the Bittensor’s economic engine unlocks global creativity to tackle tasks that were previously time-consuming, fragmented, or expensive to complete. Let’s see how quickly each company can scale and whether startups building on Bittensor can grow faster than their non-decentralized peers.

Timestamps:

0:00 Intro

2:19 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!

3:40 What is Bittensor?

7:22 Metanova Labs joins the show

9:28 Lemon.io - Get 15% off your first 4 weeks of developer time at https://Lemon.io/twist

17:16 How Metanova tackles the multi-billion dollar cost of drug discovery

20:48 Every.io - For all of your incorporation, banking, payroll, benefits, accounting, taxes or other back-office administration needs, visit https://every.io

30:20 Bitcast joins the show

31:23 Luma AI - Luma builds accessible, professional-grade AI tools for creatives. Try Luma Agents for free at https://lumalabs.ai/twist

32:30 Mining crypto with YouTube

36:48 Why Bitcast is focused on the crypto space to start

39:11 How healthy is the creator economy?

47:26 When will the AI bubble collapse?

53:44 Score joins the show

54:42 How Score will make vision AI more accessible

57:16 VLMs v. LLMs

1:01:14 Demo of the Manako platform

Subscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.com

Check out the TWIST500: https://www.twist500.com

Subscribe to This Week in Startups on Apple: https://rb.gy/v19fcp

Follow Lon:

X: https://x.com/lons

Follow Alex:

X: https://x.com/alex

LinkedIn: ⁠https://www.linkedin.com/in/alexwilhelm

Follow Jason:

X: https://twitter.com/Jason

LinkedIn: https://www.linkedin.com/in/jasoncalacanis

Check out all our partner offers: https://partners.launch.co/

Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarland

Check out Jason’s suite of newsletters: https://substack.com/@calacanis

Follow TWiST:

Twitter: https://twitter.com/TWiStartups

YouTube: https://www.youtube.com/thisweekin

Instagram: https://www.instagram.com/thisweekinstartups

TikTok: https://www.tiktok.com/@thisweekinstartups

Substack: https://twistartups.substack.com


Every week, Jason Calacanis dives headfirst into the swirling vortex of Silicon Valley and global tech with This Week in Startups. It’s a direct line to the conversations shaping our digital future, moving far beyond surface-level news. You’ll hear Jason’s unfiltered analysis on everything from market shifts and media trends to the underlying mechanics of building a business, all delivered with a blend of enthusiasm and seasoned skepticism. The core of this podcast, however, lies in the guests. Jason sits down with the very people driving change-founders who have scaled impossible heights, operators managing daily chaos, and investors who spot trends before they become obvious. These conversations are less like formal interviews and more like insider debriefs, pulling back the curtain on real strategies, painful failures, and unexpected successes. For anyone curious about how technology is built, funded, and ultimately changes the world, this series offers a front-row seat. It’s the context behind the headlines, providing a deeper understanding of the forces at play in startups and technology. Tune in for a consistently engaging and insightful look at the ecosystem, straight from someone who lives and breathes it.
Author: Language: en-us Episodes: 100

This Week in Startups
Podcast Episodes
Jason’s Top CES Products and Takeaways | E2232 [not-audio_url] [/not-audio_url]

Duration: 1:09:08
This Week In Startups is made possible by:Hubspot - http://clickhubspot.com/twist1Circle.so - http://circle.so/twistSentry - http://sentry.io/twistToday’s show: On the last TWiST episode before Jason goes to Japan and Al…
Jason’s ultimate dream mega-purchase + Founder Q’s | E2228 [not-audio_url] [/not-audio_url]

Duration: 45:03
This Week In Startups is made possible by:Northwest Registered Agent- https://www.northwestregisteredagent.com/twistVanta - http://www.vanta.com/twistLemon IO - https://lemon.io/twistToday’s show: Jason’s already a milli…
Waymo Madness in SF! Why robotaxis clogged the streets | E2227 [not-audio_url] [/not-audio_url]

Duration: 59:35
This Week In Startups is made possible by:Caldera + Lab - http://calderalab.com/TWISTCrusoe Cloud - https://crusoe.ai/buildUber - http://uber.com/twistToday’s show: Why did a power outage in the Bay Area cause Waymos to…
Level up your copywriting w/ Sam Parr | E2226 [not-audio_url] [/not-audio_url]

Duration: 1:06:13
This Week In Startups is made possible by:Luma AI - https://lumalabs.ai/twistNorthwest Registered Agent - https://www.northwestregisteredagent.com/twist Lemon IO - https://lemon.io/twistToday’s show: DID YOU KNOW… most o…
Is this the end for the Roomba? Why iRobot went bankrupt | E2224 [not-audio_url] [/not-audio_url]

Duration: 1:00:42
This Week In Startups is made possible by:Vanta - https://www.vanta.com/twistNetSuite - https://www.netsuite.com/twistLemon.io - https://lemon.io/twist*Today’s show: Domestic robots have never been hotter… so why is iRob…
Disney and OpenAI sign landmark deal… and we saw it coming! | E2223 [not-audio_url] [/not-audio_url]

Duration: 57:58
This Week In Startups is made possible by:LinkedIn Ads - http://linkedin.com/thisweekinstartupsDevStats - https://www.devstats.com/twistCrusoe - https://crusoe.ai/buildToday’s show: FINALLY, you can hang out with Kylo Re…