Mapping Cognitive Resilience: How Environment Aging and Inflammation Shape Information Encoding in the Hippocampus

Mapping Cognitive Resilience: How Environment Aging and Inflammation Shape Information Encoding in the Hippocampus

Author: UCTV April 3, 2026 Duration: 58:31
Cognitive resilience depends on how the brain responds to environment, aging, and inflammation. J. Tiago Gonçalves, Ph.D., studies the hippocampus to examine how spatial memory is shaped by factors such as cognitive enrichment, exercise, social interaction, disease, and age. Gonçalves explains how adult neurogenesis and microglia help support the brain’s ability to encode information, and how disruptions in these systems can affect memory. He also shows that aging and systemic inflammation can weaken spatial encoding while still revealing signs of adaptation and recovery over time. By connecting brain plasticity, immune activity, and memory formation, Gonçalves presents a broader view of how cognition changes across the lifespan and how these mechanisms may inform future strategies for addressing cognitive decline Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40848]

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Author: Language: en-us Episodes: 100

University of California Video Podcasts (Video)
Podcast Episodes
CARTA: The Idea Organ - Questions Answers and Closing Remarks [not-audio_url] [/not-audio_url]

Duration: 1:03:38
Humans live in a world of ideas—born in the brain, shared through language, accumulated in culture across generations, and made reality. From the first flaked stone tools to the building of shelters, from figurative and…
Where Are We Now? Bias in Health AI [not-audio_url] [/not-audio_url]

Duration: 35:15
Bias in health AI can shape who gets care, how fairly risk is measured, and whether automation helps or harms patients. Karandeep Singh, M.D., M.M.S.C. explains that predictive AI can reflect historical, representation,…
Is This Your Only Life? [not-audio_url] [/not-audio_url]

Duration: 1:20:13
Embodiment affects how we understand personhood, moral status, and whether this life is our only life. Mark Johnston, Henry Putnam University Professor, Princeton University, explains how competing theories of mind and m…
CARTA: The Costs of Big Brains with Alex Pollen [not-audio_url] [/not-audio_url]

Duration: 17:00
Human brain expansion is often discussed in terms of the genetic and molecular innovations that drove uniquely human cognitive abilities. Yet evolution is fundamentally a process of tradeoffs. Disproportionate expansion…
Artificial Intelligence in (AI-Driven) Healthcare [not-audio_url] [/not-audio_url]

Duration: 39:36
AI in healthcare raises urgent questions about bias, privacy, and power. Safiya U. Noble, Ph.D., examines how AI systems can reproduce social and racial inequities when they rely on incomplete data, hidden assumptions, a…
The Impact of AI on Business [not-audio_url] [/not-audio_url]

Duration: 44:02
Artificial intelligence is changing how businesses use data, make decisions, and organize work. UC San Diego Rady School of Management's Thomas Beyer looks at that evolution from the early push to collect as much data as…