Unpacking GLP-1s: A New Approach to Weight Health with Ashley Koff

Unpacking GLP-1s: A New Approach to Weight Health with Ashley Koff

Author: JJ Virgin February 11, 2026 Duration: 46:35
Well Beyond 40
HealthHealth & FitnessFitness
What if the goal wasn't just to lose weight, but to achieve a balanced "weight health ecosystem"? In this episode, I speak with Ashley Koff about how ultra-processed foods, under-fueling, and disrupted hormones have shaped today’s metabolic crisis—and why weight loss alone is the wrong goal. Ashley shares her deeply personal journey and her science-backed framework for understanding weight health, including a clear, honest conversation about GLP-1 medications and how to use them responsibly. Ashley Koff, RD, is the USA Today bestselling author of Your Best Shot (HarperOne) and founder of The Better Nutrition Program (BNP). With over twenty-five years of experience, Ashley’s helped redefine how we approach sustainable, lasting weight health. In her new book, Your Best Shot, Ashley introduces weight-health hormones (GLP-1, GIP, CCK, PYY) and offers the first-ever system for assessing and optimizing these hormones, whether you’re using GLP-1 medication or not. It’s a game-changer for anyone who’s felt stuck, blamed themselves, or been failed by traditional dieting. What you’ll learn: (02:10) Why ultra-processed foods undermine satiety and metabolic health. (08:05) How dieting and under-fueling can damage digestion, hormones, and muscle. (13:40) What “weight health” means and why weight alone misses the real problem. (15:30) How GLP-1 and other incretin hormones regulate appetite, fat storage, bone, and metabolism. (17:45) Why enriched and ultra-processed foods leave the body under-resourced. (21:00) How GLP-1 medications work differently from the body’s natural hormone signals. (24:10) Why fatigue, digestive issues, and muscle loss can happen on GLP-1s when dosing and nutrition aren’t optimized. (30:20) Whether it’s possible to come off GLP-1 medications and what sustainable success actually looks like. Love the podcast? Here’s what to do: Subscribe to the podcast. Leave a review. Text a screenshot to me at 813-565-2627 and wait for a personal reply because your voice is so important to me. Want to listen to the show completely ad-free? Go to http://subscribetojj.com Click “TRY FREE” and start your ad-free journey today! When you’re ready, enjoy the VIP experience for just $4.99 per month or $49.99 per year (save 17%!) Full show notes (including all links mentioned): https://jjvirgin.com/yourbestshot → BIOptimizers | Right now, you can save 15% at https://bioptimizers.com/jjvirgin and use the code JJVIRGIN. Learn more about your ad choices. Visit megaphone.fm/adchoices

Midlife isn't a crisis; it's a catalyst. On Well Beyond 40, JJ Virgin guides a conversation about rewriting the narrative of aging for women, moving from simply coping to truly thriving. This isn't about chasing youth, but about building a foundation of strength and vitality that makes the coming decades the most rewarding yet. Each episode feels like a direct, practical talk with a trusted expert who cuts through the noise. You'll hear actionable strategies rooted in science, focusing on how nutrition, movement, and mindset intersect uniquely during this life stage. JJ translates complex research into clear steps for refueling your body, managing energy, and cultivating a sense of purpose that goes far beyond the scale. The Well Beyond 40 podcast operates on the principle that knowing *why* something works is just as important as knowing *what* to do. Listeners are invited into a space where questions about metabolic shifts, hormonal balance, sustainable fitness, and intentional beauty are met with evidence-based answers and genuine empathy. It’s a resource for any woman ready to move past generic advice and discover what it means to age with power, confidence, and joy on her own terms. Tune in to reframe your approach and build a life that feels truly well-lived.
Author: Language: English Episodes: 100

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