Andrej Karpathy: Software Is Changing (Again)

Andrej Karpathy: Software Is Changing (Again)

Author: Y Combinator June 19, 2025 Duration: 39:31

Andrej Karpathy's keynote at AI Startup School in San Francisco.Drawing on his work at Stanford, OpenAI, and Tesla, Andrej sees a shift underway. Software is changing, again. We’ve entered the era of “Software 3.0,” where natural language becomes the new programming interface and models do the rest.He explores what this shift means for developers, users, and the design of software itself— that we're not just using new tools, but building a new kind of computer.


Slides provided by Andrej: https://drive.google.com/file/d/1a0h1mkwfmV2PlekxDN8isMrDA5evc4wW/view?usp=sharing


Behind every successful startup is a story, and the Y Combinator Startup Podcast is where those stories are told in full. This isn't about polished theory; it's the raw, practical conversation happening between founders who have been in the trenches and the Y Combinator partners who advise them. You'll hear directly from people who have navigated the chaotic journey from a flicker of an idea to building a company that scales, discussing not just their victories but, more importantly, the hard lessons and tactical decisions that aren't found in any textbook. Each episode feels like a candid office-hours session, stripping away the hype to focus on the real work of making something people actually want. For anyone curious about the mechanics of building a technology company-the early uncertainties, the pivotal moments, and the relentless focus on execution-this podcast offers an unfiltered look at the craft. Tune in for genuine insights from the frontlines, where the focus remains squarely on the art and science of building things that matter.
Author: Language: en-us Episodes: 100

Y Combinator Startup Podcast
Podcast Episodes
How To Avoid AI Design Slop [not-audio_url] [/not-audio_url]

Duration: 37:26
As no-code design tools become more common, so do the pitfalls. You know what they look like - the purple gradients, annoying hover effects, sections that fade as you scroll. So how do you avoid a site that feels vibe co…
The Fastest Path To Super Intelligence [not-audio_url] [/not-audio_url]

Duration: 19:45
Poetiq is a new startup founded by former DeepMind researchers that recently achieved a major jump on the ARC-AGI and Humanity's Last Exam benchmark by layering a recursive self-improvement system on top of existing mode…
The AI Agent Economy Is Here [not-audio_url] [/not-audio_url]

Duration: 23:21
With the takeoff of OpenClaw and MoltBook, a new agent-driven economy is taking shape.In this episode of the Lightcone, we took a look at the explosive growth of AI dev tools and whether the time has come for builders to…
Inside Claude Code With Its Creator Boris Cherny [not-audio_url] [/not-audio_url]

Duration: 50:10
A very special guest on this episode of the Lightcone! Boris Cherny, the creator of Claude Code, sits down to share the incredible journey of developing one of the most transformative coding tools of the AI era.
The New Way To Build A Startup [not-audio_url] [/not-audio_url]

Duration: 7:50
In the AI era, startups aren't winning by hiring faster — they're winning by automating as many internal functions as possible. In this episode of Main Function, Garry breaks down how tiny teams are beating companies 20x…
OpenClaw And The Future Of Personal AI Agents [not-audio_url] [/not-audio_url]

Duration: 22:35
You’ve probably already heard all about OpenClaw (formerly Clawdbot/Moltbot). The viral sensation is an open-source AI assistant that runs on your own device, connects with messaging apps you already use, and goes beyond…
We're All Addicted To Claude Code [not-audio_url] [/not-audio_url]

Duration: 45:59
Wondering why your maker-turned-manager suddenly seems distracted in meetings? Maybe they're addicted to coding agents! In this episode of Lightcone, Calvin French-Owen — a co-founder of Segment and former engineer on Op…
How To Get Your First Customers [not-audio_url] [/not-audio_url]

Duration: 5:41
When you're starting out, it isn’t enough to just build a minimum viable product. You also need a minimum evolvable product - one that can adapt to the needs of those critical early customers. In this episode of Main Fun…
Inside The Startup Building Reusable Rockets [not-audio_url] [/not-audio_url]

Duration: 15:43
Stoke Space is racing to build the world's first fully reusable rockets that can launch, survive reentry, and fly again and again. In this episode of Hard Tech, YC’s Aaron Epstein sits down with Stoke Space co-founders A…
What Surprised Us Most In 2025 [not-audio_url] [/not-audio_url]

Duration: 30:22
2025 was the year AI stopped feeling chaotic and started feeling buildable. In this Lightcone episode, the YC partners break down the surprises of the year, from shifting model dominance to why the real opportunity is mo…