1025 - Why Antifungal Treatment Fails (And What to Do Instead)

1025 - Why Antifungal Treatment Fails (And What to Do Instead)

Author: Dr. Michael Ruscio, DC August 16, 2026 Duration: 1:09:34

In this episode, Dr. Ruscio and Dr. Scott Spiridigliozzi break down why mold and fungal treatments often fail—and what may improve the odds of success. They discuss how to get clearer on the diagnosis, why herbal therapies may not be enough for some patients, the importance of reaching therapeutic antifungal levels, why underdosing can backfire, and how targeting the right tissues may help prevent relapse. They also share insights from their own experiences with chronic fungal illness and how those lessons are shaping their evolving treatment approach.

 

✅ Start healing with us! Learn more about our virtual clinic:  https://drruscio.com/virtual-clinic/

 

💊 Antifungal Protocol

🔹 Triple Therapy Probiotic Powder Sticks: https://store.drruscio.com/products/triple-therapy-probiotic 

🔹 Gut Rebuild Nutrients: https://store.drruscio.com/products/gut-rebuild-nutrients-powder-chocolate 

🔹 Biota-Boost: https://store.drruscio.com/products/biota-boost

🔹 Biota Resistant Starch: https://store.drruscio.com/products/biota-resistant-starch

🔹 Biota Fiber: https://store.drruscio.com/products/biota-fiber

 

🌿 Herbal Antimicrobials

🔹 Biota-Clear 1a: https://store.drruscio.com/products/biota-clear-1a

🔹 Biota-Clear 1b: https://store.drruscio.com/products/biota-clear-1b

🔹 Biota-Clear 2a: https://store.drruscio.com/products/biota-clear-2a

🔹 Biota-Clear 2b: https://store.drruscio.com/products/biota-clear-2b

 

👃 Nasal irrigation:

🔹 NeilMed Squeeze Bottle

https://shop.neilmed.com/products/sinus-rinse-bottle-3ct-and-nasadock-plus

🔹 NeilMed Xylitol

https://www.amazon.com/NeilMed-Sinus-Rinse-Xylitol-Count/dp/B08FPK73R7?th=1

🔹 NAC Packet

https://www.amazon.com/SinuMed-Packets-Allergy-Congestion-Symptoms/dp/B0FLPQFN99/

🔹 LiviaOne Probiotic Nasal Spray:

https://store.drruscio.com/products/liviaone-probiotic-nasal-spray

 

👇 Watch more videos like this 👇 

➡️ Fungus – The Hidden Reason Symptoms Keep Coming Back:

https://www.youtube.com/watch?v=lIb2DXdInv4

➡️ How to Tell If You Have Mold in Your Home (And What To Do Next):

https://www.youtube.com/watch?v=utLr0rQghfs

 

Subscribe: https://www.youtube.com/@DrRuscioDC?sub_confirmation=1

 

And if you have any questions or topics you would like covered in the future, let me know in the comments!

 

👇 Read these next 👇

➡️ Everything You Need to Know about SIFO (Small Intestinal Fungal Overgrowth):

https://drruscio.com/everything-need-know-sifo-small-intestinal-fungal-overgrowth/

➡️ Black Mold Symptoms: What's Real, What's Not, and What to Do: https://drruscio.com/black-mold-symptoms/

 

📌Timestamps

00:00 Intro 

05:25 Clues of Fungal Infection

10:32 Diagnostic Clarity

17:50  Herbal Therapy Alone Is Insufficient

19:36  Natural Fungal Protocol

23:46 Medications Must Hit Therapeutic Levels

35:56 Don't Be Timid On The Battlefield

55:35 Medications Must Hit Target Tissues



🎧Audio Episode & Featured Studies 

📉Biofilm Disruption Enhances Antimicrobial Therapy for Small Intestinal Bacterial Overgrowth and Intestinal Methanogen Overgrowth: https://pubmed.ncbi.nlm.nih.gov/41394228/

📉Itraconazole solution: higher serum drug concentrations and better clinical response rates than the capsule formulation in acquired immunodeficiency syndrome patients with candidosis: https://pubmed.ncbi.nlm.nih.gov/9378812/

📉Population pharmacokinetics of itraconazole and its active metabolite hydroxy-itraconazole in paediatric cystic fibrosis and bone marrow transplant patients: https://pubmed.ncbi.nlm.nih.gov/17048974/

📉Effect of omeprazole on the pharmacokinetics of itraconazole: https://pubmed.ncbi.nlm.nih.gov/9626921/

📉Case Study: Rapid Complete Recovery From An Autism Spectrum Disorder After Treatment of Aspergillus With The Antifungal Drugs Itraconazole And Sporanox: https://pubmed.ncbi.nlm.nih.gov/33132781/




Follow Me

Facebook - https://www.facebook.com/DrRuscio

Instagram - https://www.instagram.com/drruscio/

 

DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment.

Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g 

*Full transcript available on YouTube by clicking the "Show transcript" button on the bottom right of the video.


Trying to make sense of the latest health trends and research can feel overwhelming. Dr. Ruscio Radio, DC: Health, Nutrition and Functional Healthcare cuts through the noise with grounded, evidence-based conversations. Hosted by clinician and researcher Dr. Michael Ruscio, DC, this podcast explores the practical side of functional health, where complex science is translated into actionable steps you can use. Episodes often start with a curious question-why does one diet work for some but not others, or what does the latest study really mean for everyday health-and follow the evidence where it leads. You’ll hear deep dives into gut health, nutrition, and fitness, balanced with a critical eye that isn’t afraid to debunk popular fads when the data doesn’t support them. The tone is conversational yet precise, reflecting Dr. Ruscio’s dual role as a practicing clinician and a dedicated investigator. Each discussion is built to provide clarity, leaving you with a clearer understanding of how your body works and what might help it work better. It’s important to note that this podcast is for educational and informational purposes. While Dr. Ruscio shares his expertise as a doctor of chiropractic, the content does not constitute personal medical or professional advice. Instead, think of it as a reliable source for thoughtful analysis, helping you have more informed conversations about your own health journey.
Author: Language: English Episodes: 50

Dr. Ruscio Radio, DC: Health, Nutrition and Functional Healthcare
Podcast Episodes
1015 - 6 Powerful Tools to Reset Your Nervous System [not-audio_url] [/not-audio_url]

Duration: 37:59
In this video, Dr. Ruscio discusses 6 powerful tools to reset and calm a dysregulated nervous system. The tools he discusses include vagus nerve stimulation via the ear, resonance breathing, electrolytes / sodium optimiz…
1013 - 5 Vagus Nerve Dysfunction Symptoms (& How To Fix It) [not-audio_url] [/not-audio_url]

Duration: 39:15
If you're dealing with unexplained digestive issues, chronic stress, low libido, or irregular heart rate, your vagus nerve may be involved. In this video, I've compiled the most common signs of vagus nerve dysfunction an…
1012 - 9 Best Foods for Thyroid Health [not-audio_url] [/not-audio_url]

Duration: 22:01
Need a thyroid deep dive? See Dr. Ruscio's Thyroid Self Help Course: https://drruscio.com/thyroid-course/ In this episode, Dr. Ruscio breaks down the 9 best foods to support optimal thyroid function and why getting the r…
1010 - How to Fix SIBO & Prevent Recurrence (New Research) [not-audio_url] [/not-audio_url]

Duration: 22:12
In this episode, we break down a major factor in treating SIBO and preventing recurrence: biofilm disruption. You'll learn how to identify the telltale signs of biofilms, the steps to our proven treatment protocol, and d…
1009 - Top 5 Surprising Red Light Benefits You Didn't Know [not-audio_url] [/not-audio_url]

Duration: 26:12
Red light therapy has benefits that go far beyond skin health. In this video, I break down five surprising ways it may support your body, including brain function, thyroid health, hair growth, joint comfort, and energy l…
1008 - Best Diet to Repair Gut Health (Important New Research) [not-audio_url] [/not-audio_url]

Duration: 25:22
Could an enzyme deficiency explain why you have food intolerances causing bloating, loose bowels, reflux, brain fog, joint pain, skin issues, and more? Namely, sucrase isomaltase. This enzyme, known as the sucrase-isomal…
1007 - Top 7 Candida Warning Signs You Shouldn't Ignore [not-audio_url] [/not-audio_url]

Duration: 34:07
Persistent gut issues, brain fog, fatigue, or recurring infections may be signs of Candida overgrowth. In this video, I break down the top warning signs I see in clinical practice, how to differentiate Candida from simil…
1006 - 5 Health Problems That Are Secretly Leaky Gut [not-audio_url] [/not-audio_url]

Duration: 17:28
These common health issues could be warning signs of leaky gut. If you're dealing with fatigue, autoimmune symptoms, or ongoing digestive problems, your gut may be at the root. Watch now to learn what to look for and wha…