Microglia, Metabolism & the Future of Brain Health | HOMe Podcast #005

Microglia, Metabolism & the Future of Brain Health | HOMe Podcast #005

Author: Health Optimization Medicine and Practice April 8, 2026 Duration: 59:00

In this episode of the Health Optimization Medicine Podcast, Dr. Scott Sherr is joined by renowned neurologist and bestselling author Dr. David Perlmutter to explore one of the most important breakthroughs in brain health — the role of microglia.

Often overlooked, microglial cells are the brain's immune system and play a central role in determining whether the brain thrives or degenerates over time.

Dr. Perlmutter explains how these cells can shift between protective (M2) and destructive (M1) states — and how this shift underlies neurodegenerative diseases like Alzheimer's, Parkinson's, and more.

Most importantly, this episode highlights how everyday lifestyle choices — from diet and exercise to metabolic health — directly influence brain function and long-term cognitive resilience.

Join us as we delve into:

  • What microglia are and why they control brain health
  • The difference between M1 (destructive) and M2 (protective) states
  • How metabolism shapes the brain's immune response
  • Why conditions like Alzheimer's are rooted in immune dysfunction
  • The connection between blood sugar, insulin, and brain degeneration

This episode is for you if:

  • You want to protect your brain and prevent cognitive decline
  • You're interested in the science of Alzheimer's and neurodegeneration
  • You want actionable strategies to improve brain health
  • You're curious about the future of brain optimization and longevity

You can also find this episode on…
Youtube: https://youtu.be/EMrlchMOZKk

Find more from Dr. David Perlmutter
Website: https://www.drperlmutter.com
Book: https://braindefenders.com
LinkedIn: https://www.linkedin.com/in/david-perlmutter-md/
Instagram: https://www.instagram.com/davidperlmutter/
Facebook: https://www.facebook.com/DavidPerlmutterMd/

Find more from Health Optimization Medicine and Practice (HOMeHOPe):
Website: https://homehope.org/
Instagram: https://www.instagram.com/homehopeorg/
Virtual Symposium 2026: https://homehope.org/homehope-virtual-symposium-2026
Use PODCAST10 to get 10% OFF your purchase of the Clinical Metabolomics Module at https://homehope.org/products/clinical-metabolomics

Find more from Troscriptions
Website: https://troscriptions.com/
Instagram: https://www.instagram.com/troscriptions/
Use POD10 to get 10% OFF your Troscriptions purchase at https://troscriptions.com/collections/our-products


Dive deep into the conversations that move beyond conventional wellness advice with the Health Optimization Medicine Podcast. Here, the focus is on practical, accessible strategies for complex challenges in health, performance, and conscious living. This series is built on a foundational idea: finding simple, effective solutions-the one-cent answers-to life's most expensive and demanding questions. It’s a space where rigorous scientific inquiry meets tangible, clinical practice, all designed for those looking to elevate their daily function and long-term potential. Produced through a collaboration between Smarter Not Harder, Inc., the makers of Troscriptions, and Health Optimization Medicine & Practice (HOMeHOPe), each episode unfolds as an in-depth dialogue. You’ll hear experts unpack the nuances of decision-making, consciousness, and systemic health, translating dense research into actionable insights you can apply. The discussions avoid superficial tips, favoring instead a holistic exploration of what it means to truly optimize the human experience. Tune into this podcast for a thoughtful, evidence-based journey toward becoming smarter, not harder, in your approach to your own well-being and capabilities.
Author: Language: English Episodes: 100

Health Optimization Medicine Podcast
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