Longevity Scientist Shares Top Strategies for Improving Your Health Span w/ Matt Kaeberlein, PhD

Longevity Scientist Shares Top Strategies for Improving Your Health Span w/ Matt Kaeberlein, PhD

Author: Mike Mutzel shares interviews with Peter Attia, Jason Fung, Stan Efferding, September 7, 2024 Duration: 1:29:44

Today's show is brought to you by MYOXCIENCE Nutrition. In this episode Matt Kaeberlein, PhD, CEO of Optispan, discusses the significance of enhancing health span through interventions like rapamycin and highlights the role of senescent cells in chronic inflammation and age-related diseases.

Crush your workouts with the Creatine+ Electrolyte Combo by MYOXCIENCE: https://bit.ly/Electrolyte-Stix-Jar
*Save with code podcast at checkout

Link to show notes: https://bit.ly/4gdmxES

Key Takeaways: 

  • 02:44 Pillars of health: eat, sleep, move, connect.
  • 10:30 Eating protein and exercise can turn up mTOR.
  • 15:20 High dietary protein and resistance training preserves muscle while aging.
  • 19:20 Longevity research is underfunded.
  • 25:10 Obesity was rare 50 years ago.
  • 26:25 Fasting, and time restricting eating may not increase longevity.
  • 30:45 Smoking, sedentary life, alcohol consumption and obesity shorten lifespan.
  • 34:40 Resveratrol is not a longevity drug.
  • 36:45 Spermidine is an autophagy booster.
  • 38:10 Alpha ketoglutarate, urolithin A, and NAD precursors, may increase lifespan.
  • 42:45 Acarbose, SGLT-2 inhibitors, and estrogens can increase lifespan.
  • 44:45 Metformin does not corelate to reduced all-cause mortality.
  • 47:30 NAD is a co-factor required for thousands of metabolic reactions.
  • 52:55 Some epigenetic signatures are predictive of future health outcomes.
  • 54:17 Facial imaging using AI can predict future health outcomes.
  • 58:17 Dunedin Pace measures the rate of aging.
  • 59:40 Optispan looks at epigenetics, blood glycan, and immune resilience/aging.
  • 01:04:00 Senescent cells are cells that do not do their job and refuse to die.
  • 01:07:50 Rapamycin impacts senescent cells, autoimmunity, and inflammation.

     


Tune into High Intensity Health with Mike Mutzel, MS for conversations that cut through the noise of mainstream wellness trends. Host Mike Mutzel, who holds a Master of Science degree, sits down with leading researchers and practitioners like Peter Attia, Jason Fung, and Stan Efferding to explore the science behind lasting health. This podcast delves into the interconnected systems of the human body, moving beyond simplistic advice to discuss metabolic flexibility, gut health, and immune function with a level of detail you won't find everywhere. Each episode is a deep dive, whether the topic is nutritional strategies for reducing body fat, protocols for enhancing mental clarity, or training principles for elite athletic performance. The dialogue is grounded in functional medicine and evidence-based practices, offering actionable insights rather than just theory. Listeners gain access to the nuanced, often insider perspectives that these experts share with their own clients and patients. It’s for anyone-parents, professionals, clinicians, or athletes-who wants to understand the *why* behind their health decisions and take a more strategic approach to their own well-being. You'll finish an episode of this podcast not just with tips, but with a clearer framework for making informed choices about nutrition, fitness, and overall longevity.
Author: Language: English Episodes: 50

High Intensity Health with Mike Mutzel, MS
Podcast Episodes
Grass-Fed VS Grain-Fed: A Rancher's Take on Beef & Nutrient Quality [not-audio_url] [/not-audio_url]

Duration: 1:06:51
Rancher Michaela Mann discusses the balance between grass and grain finishing in cattle and challenges faced by U.S. agriculture including land loss and sustainability efforts. Crush your Workouts and stay hydrated this…
Vegetable Oils Worse Than Animal Fats: 2 Studies Challenge Diet Myths [not-audio_url] [/not-audio_url]

Duration: 19:29
A reanalysis of the Minnesota Coronary Experiment, a large randomized controlled trial, which found that reducing saturated fat and replacing it with vegetable oils did not lower the risk of heart disease or death despit…
Half of Cancer Deaths Are Preventable with These Lifestyle Changes [not-audio_url] [/not-audio_url]

Duration: 12:42
A new study finds over 40% of cancer deaths in the US are preventable through lifestyle changes such as reducing smoking, alcohol consumption, and obesity, while promoting exercise and a healthy diet, with a specific foc…
Beyond LDL-Cholesterol: These Culprits Drive Artery Plaque Build Up [not-audio_url] [/not-audio_url]

Duration: 22:16
For the past 60 years the medical community has obsessively focused on lowering LDL-cholesterol levels… Research shows these five preventable health conditions make LDL-Cholesterol more likely to cause artery plaque buil…
Science Behind Vitamin D and A Synergy [not-audio_url] [/not-audio_url]

Duration: 10:09
New research suggests vitamin D and A work better when they're taken together. Here's more food for thought... Support your Vitamin D, K2 + A Health with this combo by MYOXCIENCE: by MYOXCIENCE: https://bit.ly/vitamin-d-…
Vitamin D, Sun Exposure & Testosterone w/ Mark Bell + Nsima Inyang [not-audio_url] [/not-audio_url]

Duration: 48:41
Mark Bell and Nsima Inyang delve into the transformative benefits of sunlight and outdoor activity for enhancing hormone levels, accelerating fat loss, and improving overall health. Crush your Workouts and stay hydrated…
Peptides for Growth Hormone + Hormonal Balance w/ Dr. Elana Zinkov [not-audio_url] [/not-audio_url]

Duration: 56:17
Dr. Zinkov discusses ways to use peptides therapeutically to improve tissue rejuvenation and repair, promote longevity, enhance muscle growth, and boost mood, vitality, and libido. She discusses the benefits and risks, s…
Skipping Breakfast & Weight Gain: The Surprising Link Exposed [not-audio_url] [/not-audio_url]

Duration: 10:20
The relationship between breakfast, sleep, and weight is complex. While skipping breakfast has been traditionally linked with weight gain, new evidence emphasizes the critical role of adequate sleep in maintaining a heal…