Longevity Scientist Shares Top Strategies for Improving Your Health Span w/ Matt Kaeberlein, PhD

Longevity Scientist Shares Top Strategies for Improving Your Health Span w/ Matt Kaeberlein, PhD

Author: Mike Mutzel shares interviews with Peter Attia, Jason Fung, Stan Efferding, September 7, 2024 Duration: 1:29:44

Today's show is brought to you by MYOXCIENCE Nutrition. In this episode Matt Kaeberlein, PhD, CEO of Optispan, discusses the significance of enhancing health span through interventions like rapamycin and highlights the role of senescent cells in chronic inflammation and age-related diseases.

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Link to show notes: https://bit.ly/4gdmxES

Key Takeaways: 

  • 02:44 Pillars of health: eat, sleep, move, connect.
  • 10:30 Eating protein and exercise can turn up mTOR.
  • 15:20 High dietary protein and resistance training preserves muscle while aging.
  • 19:20 Longevity research is underfunded.
  • 25:10 Obesity was rare 50 years ago.
  • 26:25 Fasting, and time restricting eating may not increase longevity.
  • 30:45 Smoking, sedentary life, alcohol consumption and obesity shorten lifespan.
  • 34:40 Resveratrol is not a longevity drug.
  • 36:45 Spermidine is an autophagy booster.
  • 38:10 Alpha ketoglutarate, urolithin A, and NAD precursors, may increase lifespan.
  • 42:45 Acarbose, SGLT-2 inhibitors, and estrogens can increase lifespan.
  • 44:45 Metformin does not corelate to reduced all-cause mortality.
  • 47:30 NAD is a co-factor required for thousands of metabolic reactions.
  • 52:55 Some epigenetic signatures are predictive of future health outcomes.
  • 54:17 Facial imaging using AI can predict future health outcomes.
  • 58:17 Dunedin Pace measures the rate of aging.
  • 59:40 Optispan looks at epigenetics, blood glycan, and immune resilience/aging.
  • 01:04:00 Senescent cells are cells that do not do their job and refuse to die.
  • 01:07:50 Rapamycin impacts senescent cells, autoimmunity, and inflammation.

     


Tune into High Intensity Health with Mike Mutzel, MS for conversations that cut through the noise of mainstream wellness trends. Host Mike Mutzel, who holds a Master of Science degree, sits down with leading researchers and practitioners like Peter Attia, Jason Fung, and Stan Efferding to explore the science behind lasting health. This podcast delves into the interconnected systems of the human body, moving beyond simplistic advice to discuss metabolic flexibility, gut health, and immune function with a level of detail you won't find everywhere. Each episode is a deep dive, whether the topic is nutritional strategies for reducing body fat, protocols for enhancing mental clarity, or training principles for elite athletic performance. The dialogue is grounded in functional medicine and evidence-based practices, offering actionable insights rather than just theory. Listeners gain access to the nuanced, often insider perspectives that these experts share with their own clients and patients. It’s for anyone-parents, professionals, clinicians, or athletes-who wants to understand the *why* behind their health decisions and take a more strategic approach to their own well-being. You'll finish an episode of this podcast not just with tips, but with a clearer framework for making informed choices about nutrition, fitness, and overall longevity.
Author: Language: English Episodes: 50

High Intensity Health with Mike Mutzel, MS
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