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Mental health is not a simple checklist, it is a whole body story. In this hol+ episode, Dr. Taz sits down with Dr. James Greenblatt, a pioneer of integrative and nutritional psychiatry, to rethink how we approach depression, anxiety, ADHD, and eating disorders through labs, nutrients, hormones, and personalized care.
Together, they unpack why so much suffering persists despite more medications, how root cause testing changes outcomes, and why simple shifts like correcting vitamin D, B12, iron, thyroid, zinc, and omega 3 can transform mood and resilience. They also explore nutrigenomics for precision dosing, the real limits of 10 minute telehealth med checks, and where tools like ketamine, psychedelics, and lithium orotate fit only after foundations are in place.
From practical lab targets and cost effective protocols to the crossroads of food, sleep, screens, and ADHD, this conversation invites us to see mental health not as a diagnosis to medicate, but as a system to understand and support.
Dr. Taz and Dr. Greenblatt discuss:
- The gap between symptom focused care and root cause testing
- Key labs for mood, vitamin D, B12, iron, thyroid, hormones
- Why micronutrients come first for eating disorders
- MTHFR, methylfolate, glutathione, and antidepressant response
- Nutrigenomics for personalized vitamin and mineral dosing
- The risks of quick med stacking and 10 minute checks
- Where ketamine, psychedelics, and lithium orotate may help, and when they do not
- ADHD, ultra processed foods, sugary drinks, sleep, and screen time
About Dr. James Greenblatt, MD
Dr. James Greenblatt, MD is a board certified psychiatrist and a pioneer of integrative and nutritional psychiatry. For more than three decades he has treated patients with ADHD, depression, anxiety, and eating disorders using personalized protocols that combine conventional care with targeted nutrients and lab guided precision. He is the author of multiple books including Finally Focused and the upcoming Finally Hopeful.
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00:00 Introduction, testing gap and the B12 tragedy
01:31 Pharma model and 10 minute med checks
02:37 Framing the crisis and why patients feel stuck
05:49 How psychiatry arrived at symptom based meds
07:29 What to test, hormones and core nutrients
10:49 The Whole Body Map explained
12:39 Vitamin D, B12, iron, thyroid, practical targets
17:52 Why meds fail without nutrition
18:23 Eating disorders, zinc, omega 3, methylfolate
24:33 MTHFR, folate, and glutathione
26:34 Nutrigenomics and personalized dosing
29:51 Ketamine and psychedelics, proceed with caution
32:26 Lithium orotate, irritability and dementia research
38:57 Polypharmacy, slowing down, doing the work
43:21 ADHD, diet, sleep, screens, lifestyle links
46:28 Where to learn more, resources, closing
- (00:00) - Chapter 1
- (00:00) - Introduction, testing gap and the B12 tragedy
- (01:31) - Pharma model and 10 minute med checks
- (02:37) - Framing the crisis and why patients feel stuck
- (05:49) - How psychiatry arrived at symptom based meds
- (07:29) - What to test, hormones and core nutrients
- (10:49) - The Whole Body Map explained
- (12:39) - Vitamin D, B12, iron, thyroid, practical targets
- (17:52) - Why meds fail without nutrition
- (18:23) - Eating disorders, zinc, omega 3, methylfolate
- (24:33) - MTHFR, folate, and glutathione
- (26:34) - Nutrigenomics and personalized dosing
- (29:51) - Ketamine and psychedelics, proceed with caution
- (32:26) - Lithium orotate, irritability and dementia research
- (38:57) - Polypharmacy, slowing down, doing the work
- (43:21) - ADHD, diet, sleep, screens, lifestyle links
- (46:28) - Where to learn more, resources, closing
