Disentangling the Impact of Adiposity From Insulin Resistance in HFpEF | JACC Deep Dive

Disentangling the Impact of Adiposity From Insulin Resistance in HFpEF | JACC Deep Dive

Author: American College of Cardiology May 6, 2025 Duration: 6:19

In a Deep Dive in our May 13 issue, Editor-in-Chief Harlan Krumholz, MD, SM, FACC, discusses a study led by Barry Borlaug that investigates whether excess weight or metabolic dysfunction has a greater impact on heart failure with preserved ejection fraction (HFpEF). The findings showed that obesity—more than insulin resistance—was strongly associated with worse hemodynamic and functional outcomes. Reviewers praised the study's nuanced approach and use of invasive measures, while editorialists emphasized the ongoing importance of addressing both adiposity and metabolic health in HFpEF management.


Every week, the editors of one of the world's leading cardiology journals sit down for a conversation that goes beyond the printed page. JACC This Week, from the American College of Cardiology, brings together Editor-in-Chief Dr. Harlan Krumholz and Senior Consulting Editor Dr. Carolyn S.P. Lam. Their discussions provide essential context for the complex research published in the Journal of the American College of Cardiology, translating high-level science into meaningful insights. You’ll hear them dissect new studies, debate emerging trends, and explore the real-world implications of the latest findings in cardiovascular medicine. This isn't just a summary of the issues; it's a dialogue about how evidence is shaping modern heart care, from prevention to advanced intervention. The podcast serves as a direct line to the experts who are curating the science that defines global standards. Each episode feels like joining an informed, behind-the-scenes editorial meeting, where the nuances of patient care and clinical practice are thoughtfully examined. For anyone invested in cardiology-whether a practicing clinician, a researcher, or a dedicated student-this regular audio companion offers clarity and a deeper understanding of the forces driving the field forward. It’s where the published data meets practical conversation, all through the accessible format of a weekly podcast.
Author: Language: English Episodes: 100

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