What We Learned About the Brain in 2025 | Stress, Perception & Healing

What We Learned About the Brain in 2025 | Stress, Perception & Healing

Author: Sarah Ann Macklin December 31, 2025 Duration: 47:19

What if the qualities you’ve been taught to override are actually the ones keeping you well?


To round of 2025, I’m joined by world-leading thinkers including Simon Sinek, Dr. Rick Doblin, Robin Sharma, Professor Nicolau, and Dr. Sarah McKay to explore what truly shapes our wellbeing when the noise fades and the signal becomes clearer.


This episode weaves together some of the most powerful moments from conversations across the year. From introversion and energy boundaries, to trauma, inflammation, digital overload, recovery, and the stories we tell about our bodies, this is a reminder that health is not about optimisation, it’s about understanding cost, context, and care.


Across neuroscience, psychology, leadership, and physiology, a shared truth emerges. Our systems are intelligent. But they are not limitless. And when we listen earlier, we protect ourselves from paying a higher price later.


Here’s What We Dive Into:


- How introversion can be a strength in leadership, communication, and meaningful connection.


- Why wellbeing is less about right versus wrong, and more about understanding personal cost.


- How MDMA


-assisted therapy works in the brain to support healing from PTSD — and why context matters more than the compound.


- What recovery actually looks like in a world that rewards constant output.


- Why strategic rest and “going ghost” can unlock creativity, clarity, and long-term performance.


- How social media content — not just screen time — may drive inflammation and immune stress.


- Why chronic stress and burnout can permanently shift our inflammatory baseline.


- How cultural narratives shape emotional experiences, including PMS and mood changes.


Love,

Sarah Ann 💛


***


This episode is sponsored by:


NOWATCH: The compassionate health trackerConnecting body and mind with unique stress recovery insights so you can live fully today15% off with code LWBW15 at nowatch.com


***


Let’s be friends!

📷 Instagram: / sarahannmacklin

📹 Subscribe: / @livewellbewellsarah

🐦 Twitter: / sarahannmacklin

📱 TikTok: / sarahannnutrition

💌 Newsletter: https://sarahmacklin.substack.com/


***


Sign up to Sarah’s Compassionate Cure newsletter:Science Simplified, Health Humanised.Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact.https://sarahmacklin.substack.com/


👉 Practical beats perfect.Here’s a free 5-recipe PDF I use to support energy and stress during busy weeks.https://open.substack.com/pub/sarahmacklin/p/download-your-free-5-recipes-to-relieve


👉 If this resonates, you can join the thousands who readThe Compassionate Cure each week. https://sarahmacklin.substack.com/



***


If You Enjoyed This Episode, You Might Also Like:


Simon Sinek on Leadership, Energy, and Meaningful WorkSimon Sinek: The ADHD Superpower - Why It’s My Greatest Advantage


Dr. Rick Doblin on Trauma, Healing, and Psychedelic ScienceHow Psychedelics Change the Brain: MDMA, Psilocybin, Benefits & Risks | Dr. Rick Doblin


Dr. Sarah McKay on Women’s Brains, Hormones, and Emotional HealthWomen's Brain Health: What Science REALLY Says About Hormones, PMS & Menopause | Dr Sarah McKay


***


Highlights:


00:00:00 Intro

00:02:00 My ADHD Superpower - Why it’s my greatest advantage | Simon Sinek

00:11:23 How Psychedelics Change the Brain: MDMA, Psilocybin, Benefits and Risks | Dr Rick Doblin

00:18:51 Stop Chasing Money: 8 Hidden Forms of Wealth You Need Now | Robin Sharma

00:24:05 The Brain Immune Expert: Alert! Social Media is Reprogramming Your Immune System | Dr Dan Nicolau Jr

00:39:24 Women’s Brain Health: What Science Really Says About Hormones, PMS, and Menopause | Dr Sarah McKay


***

Love what you’re hearing?

My small ask is to please rate and review Live Well Be Well. This helps the show expand and allows me to keep producing these with the best quality guests. It means a huge amount to me, so thank you.


There's a lot of noise out there about what it means to be healthy, and Live Well Be Well with Sarah Ann Macklin cuts straight through it. Sarah Ann brings a grounded perspective shaped by both personal experience and formal study, moving beyond quick fixes to explore what sustainable wellness actually looks like. Each conversation in this podcast feels like a thoughtful exploration rather than a lecture, tackling the interconnected areas of holistic health, practical nutrition, and realistic lifestyle shifts. You'll hear from a range of insightful guests alongside Sarah Ann's own reflections, all aimed at making sense of the information overload. The tone is refreshingly human-this isn't about perfection, but about finding a smarter, more integrated approach to everyday living. Tuning into this podcast feels like gaining a knowledgeable, empathetic friend who believes that feeling well shouldn't feel like a constant struggle. It’s a space for anyone wanting to move past the confusion and cultivate a genuine sense of vitality that fits into a real, busy life.
Author: Language: English Episodes: 100

Live Well Be Well with Sarah Ann Macklin | Health, Lifestyle, Nutrition
Podcast Episodes
The Biology of Health & Longevity | Top Expert Insights from 2025 [not-audio_url] [/not-audio_url]

Duration: 1:01:23
👉 Practical beats perfect.Here’s a free 5-recipe PDF I use to support energy and stress during busy weeks.https://sarahannmacklin.com/5_free_recipes👉 If this resonates, you can join the thousands who readThe Compassionat…
Happy Holidays | Thank You for Being Part of This Journey [not-audio_url] [/not-audio_url]

Duration: 2:10
👉 Join thousands in exploring actionable insights that prioritise compassion, clarity, and real-life impact.https://sarahmacklin.substack.com/During this special holiday, I wanted to pause for a moment. Not to teach or a…