Aging is best explained by declining mitochondrial function over time.

Aging is best explained by declining mitochondrial function over time.

Author: Chris Masterjohn, PhD December 9, 2025 Duration: 3:16
 
Aging is best explained by declining mitochondrial function over time.
 
This answers its own "why."
 
Mitochondria produce the energy needed for repair so if any of it gets lost it sets up a vicious cycle. And some *always* gets lost.
 
But how much is under your control.
 
From Joe Rogan Experience JRE 2420.
 
It's a vicious cycle initiated by the second law of thermodynamics which requires a constant input of energy to prevent the collapse of order.
 
Hence, there will always be slippage, but how much slippage depends on genetics, environment, and behavior, and all slippage leads to loss of mitochondrial repair, which itself directly causes the loss of repair capacity as it weakens the defense against the imperative of the second law of thermodynamics.

Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 712

Mastering Nutrition
Podcast Episodes
Depression Starts In Your Mitochondria [not-audio_url] [/not-audio_url]

Duration: 6:47
You could be one metabolic bottleneck away from feeling amazing. Mitome is the first at-home test that measures your cellular energy directly and gives you a personalized roadmap to optimize energy, slow aging, and prote…
Mitochondria: Why They Control Everything in Human Health [not-audio_url] [/not-audio_url]

Duration: 1:42:57
Mitochondria govern everything. Watch this with the slides here: https://www.youtube.com/watch?v=mED1_L3wZbc Mitochondria convert your food to usable energy in the form of ATP, which is used to produce, maintain, repair,…
SSRI Withdrawal Is Mitochondrial Dysfunction [not-audio_url] [/not-audio_url]

Duration: 1:29:04
Chris Masterjohn, PhD, Founder and Scientific Director of mito.me, explains why SSRI withdrawal is mitochondrial dysfunction and what to do about it. This is not medical advice, diagnosis, or treatment. 29 million Americ…
How Lactate Alkalinizes Your Muscles [not-audio_url] [/not-audio_url]

Duration: 1:34:50
For a long time, most people believed that when we exercise, our muscles make lactic acid, this acidifies the muscles, and the acidity contributes to contractile failure, fatigue, and delayed-onset muscle soreness. Some…
D-Lactate: Groundbreaking Research No One Is Talking About [not-audio_url] [/not-audio_url]

Duration: 1:30:24
D-lactate is commonly stated to be exclusively a microbial metabolite. This is found in assumptions within the medical literature for decades even when it was long-known to be false. While D-lactate is indeed made by bac…
Handling Creatine Side Effects [not-audio_url] [/not-audio_url]

Duration: 2:02
In this podcast we cover elevated creatinine, insomnia, cramps constipation, water retention, hair loss, irritation and anger, lightheadedness during lifting, bloating, aggravation of restless leg syndrome, irritation of…
Your Cells Are Starving For Creatine [not-audio_url] [/not-audio_url]

Duration: 28:47
Creatine is like your second mitochondria. Or, the mitochondria's chief of staff. Or its co-pilot. Your mitochondria make ATP so you can see clearly, hear accurately, digest your food, power your brain, show off your you…