Aging is best explained by declining mitochondrial function over time.

Aging is best explained by declining mitochondrial function over time.

Author: Chris Masterjohn, PhD December 9, 2025 Duration: 3:16
 
Aging is best explained by declining mitochondrial function over time.
 
This answers its own "why."
 
Mitochondria produce the energy needed for repair so if any of it gets lost it sets up a vicious cycle. And some *always* gets lost.
 
But how much is under your control.
 
From Joe Rogan Experience JRE 2420.
 
It's a vicious cycle initiated by the second law of thermodynamics which requires a constant input of energy to prevent the collapse of order.
 
Hence, there will always be slippage, but how much slippage depends on genetics, environment, and behavior, and all slippage leads to loss of mitochondrial repair, which itself directly causes the loss of repair capacity as it weakens the defense against the imperative of the second law of thermodynamics.

Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 712

Mastering Nutrition
Podcast Episodes
Methylene Blue in 10 Minutes [not-audio_url] [/not-audio_url]

Duration: 9:57
Watch the full-length video here: https://www.youtube.com/watch?v=XhgGGbdw4zE&t=8621s Get my free 51--page report, Methylene Blue: Biohacker's Delight or Playing With Fire?, here: https://chrismasterjohnphd.substack.com/…
Methylene Blue: Biohacker's Delight, or Playing With Fire? [not-audio_url] [/not-audio_url]

Duration: 1:18:20
Get the written and referenced version here: https://chrismasterjohnphd.substack.com/p/the-guide-to-methylene-blue This is a 51-page guide in which you will learn the following: The Origin of Methylene Blue The Entry of…
Why Would Citrate or Malate Cause Insomnia? [not-audio_url] [/not-audio_url]

Duration: 31:04
This is now subscribers-only and is available here: https://chrismasterjohnphd.substack.com/p/why-would-citrate-or-malate-cause Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitom…
What to Do About Constipation [not-audio_url] [/not-audio_url]

Duration: 41:52
This is now subscribers-only and can be accessed here: https://chrismasterjohnphd.substack.com/p/what-to-do-about-constipation Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome…
How to slow or reverse graying of hair? | Masterjohn Q&A Files #321 [not-audio_url] [/not-audio_url]

Duration: 22:17
Question: How to slow graying of hairs and potentially reverse it? Short Answer: What works for any given individual will likely be to find the weakest link and fix it, from among the following systems: the signaling of…
How Much Iron Can We Absorb At Once? | Masterjohn Q&A Files #320 [not-audio_url] [/not-audio_url]

Duration: 28:20
Question: How much iron can we absorb at once? Short Answer: High-dose iron will produce more total absorbed iron, but will also leave more in the gut, which could cause constipation or disturb the gut microbiome. If des…