Aging is best explained by declining mitochondrial function over time.

Aging is best explained by declining mitochondrial function over time.

Author: Chris Masterjohn, PhD December 9, 2025 Duration: 3:16
 
Aging is best explained by declining mitochondrial function over time.
 
This answers its own "why."
 
Mitochondria produce the energy needed for repair so if any of it gets lost it sets up a vicious cycle. And some *always* gets lost.
 
But how much is under your control.
 
From Joe Rogan Experience JRE 2420.
 
It's a vicious cycle initiated by the second law of thermodynamics which requires a constant input of energy to prevent the collapse of order.
 
Hence, there will always be slippage, but how much slippage depends on genetics, environment, and behavior, and all slippage leads to loss of mitochondrial repair, which itself directly causes the loss of repair capacity as it weakens the defense against the imperative of the second law of thermodynamics.

Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 712

Mastering Nutrition
Podcast Episodes
What's the best prenatal nutrition? | Masterjohn Q&A Files #161 [not-audio_url] [/not-audio_url]

Duration: 7:29
Question: What's the best prenatal nutrition?The things that sort of stick out to me are, you don't want to be Vitamin A deficient or Vitamin A toxic, so you're right in the middle of the range. You really don't want to…
How to approach chronic joint pain? | Masterjohn Q&A Files #159 [not-audio_url] [/not-audio_url]

Duration: 10:51
Question: How to approach chronic joint pain?You definitely want to move the joints that are affected.So the movement must target the joints that are affected. And you definitely want like 30 minutes a day of just modera…
How should I break a 36-hour fast? | Masterjohn Q&A Files #158 [not-audio_url] [/not-audio_url]

Duration: 5:44
Question: How should I break a 36-hour fast?The two things that I would think about are your digestion, it's probably going to take a little bit of time to ramp itself up. I don't think you're going to do any harm by eat…
What are optimal levels of B12? | Masterjohn Q&A Files #157 [not-audio_url] [/not-audio_url]

Duration: 11:08
Question: What are optimal levels of B12? So there's a paper called the Pathophysiology of Elevated Vitamin B12 in clinical practice that PM Schoenfeld, another Masterpass member, had given me. And this paper is very int…