Aging is best explained by declining mitochondrial function over time.

Aging is best explained by declining mitochondrial function over time.

Author: Chris Masterjohn, PhD December 9, 2025 Duration: 3:16
 
Aging is best explained by declining mitochondrial function over time.
 
This answers its own "why."
 
Mitochondria produce the energy needed for repair so if any of it gets lost it sets up a vicious cycle. And some *always* gets lost.
 
But how much is under your control.
 
From Joe Rogan Experience JRE 2420.
 
It's a vicious cycle initiated by the second law of thermodynamics which requires a constant input of energy to prevent the collapse of order.
 
Hence, there will always be slippage, but how much slippage depends on genetics, environment, and behavior, and all slippage leads to loss of mitochondrial repair, which itself directly causes the loss of repair capacity as it weakens the defense against the imperative of the second law of thermodynamics.

Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 712

Mastering Nutrition
Podcast Episodes
Nutrition in Neuroscience Part 2 | Mastering Nutrition #41 [not-audio_url] [/not-audio_url]

Duration: 1:39:04
Part 2 of how NUTRITION has a HUGE impact on your BRAIN! Everything in your brain is something you ate, something you made from something you ate, or, in a few cases, something your mother ate. Nutrition impacts your men…
A New Paradigm for Severe COVID [not-audio_url] [/not-audio_url]

Duration: 1:10:46
This new model I developed explains how the depletion of arginine and tryptophan and the sequestration of cysteine leads to T cell suppression in severe COVID and may reflect the rapid onset of a somewhat cancer-reminisc…
Can Regenerative Agriculture Solve the Food Crisis? [not-audio_url] [/not-audio_url]

Duration: 1:32:48
Rising Food Prices Part 4: Can Regenerative Agriculture Solve the Food Crisis? This is the 4th in a series of interviews I am conducting to try to better understand why food prices have been rising, where they are going…
Rising Food Prices Part 3: The Commodity Trade [not-audio_url] [/not-audio_url]

Duration: 46:43
Tony Greer joins me to talk about how lockdowns, politics, and the commodity trade contribute to rising food prices. Tony Greer is partly responsible for my awareness of the emerging food crisis as I had initially learne…
Rising Food Prices Part 2: "Money Printing" [not-audio_url] [/not-audio_url]

Duration: 1:07:22
With Dr. Michael Howell, PhD. This is the second in a series of interviews I am conducting to try to better understand why food prices have been rising, where they are going as we move toward a potential food crisis, how…
Rising Food Prices Part 1: Oil and Fertilizer [not-audio_url] [/not-audio_url]

Duration: 1:28:54
This is the first in a series of interviews I am conducting to try to better understand why food prices have been rising, where they are going as we move toward a potential food crisis, how this will impact the evolving…
The Spike Protein As a Pore-Forming Toxin [not-audio_url] [/not-audio_url]

Duration: 55:19
The spike protein pokes holes in cell membranes at concentrations much lower than those achieved with vaccination, contributing to COVID-like illness and mitochondrial damage. But is the J&J immune? This is not medical a…
The Emerging Food Crisis [not-audio_url] [/not-audio_url]

Duration: 34:13
My tentative view on what is causing it and what to do about it. This is NOT caused primarily by the conflict in Ukraine and a sudden peaceful solution to the conflict will not avert it. The written version with links to…