Depression Starts In Your Mitochondria

Depression Starts In Your Mitochondria

Author: Chris Masterjohn, PhD December 16, 2025 Duration: 6:47

You could be one metabolic bottleneck away from feeling amazing.

Mitome is the first at-home test that measures your cellular energy directly and gives you a personalized roadmap to optimize energy, slow aging, and protect against disease.

Find it at mito.me 

This is not medical advice and is for educational purposes only.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 712

Mastering Nutrition
Podcast Episodes
Can Fat Fuel the Athlete? | Mastering Nutrition #33 [not-audio_url] [/not-audio_url]

Duration: 1:21:41
In this episode, we look at whether fat can fuel the athlete. We begin with the physiological principles involved, then take a look at the evidence from studies swapping fat for carbs to see how it impacts athletic perfo…
Is Coconut Oil Killing Us? | Mastering Nutrition #32 [not-audio_url] [/not-audio_url]

Duration: 1:33:44
In this episode, I weigh in on the American Heart Association's new Presidential Advisory and Dietary Fats and Cardiovascular Disease, and all the headlines that have been spinning on the supposed risks of coconut oil. T…
Why You Should Eat Glutathione | Mastering Nutrition #31 [not-audio_url] [/not-audio_url]

Duration: 1:19:06
In episode 31, I explain why glutathione survives digestion and can be absorbed intact, and why supplementing with it or eating it in foods helps support your health. My recommended supplements: Jarrow Reduced Glutathion…