In episode 31, I explain why glutathione survives digestion and can be absorbed intact, and why supplementing with it or eating it in foods helps support your health.
My recommended supplements: Jarrow Reduced Glutathione and Core Med Science Optimized Liposomal Glutathione. In most cases, save money by trying Jarrow first.
Use the discount code from this episode to sign up for Masterclass With Masterjohn Pro with a $20/year lifetime discount, offer ending May 13.
This episode is a companion to Consuming Glutathione in Foods and Supplements, which has a searchable database of glutathione in 285 foods.
This episode is brought to you by US Wellness Meats. I use their liverwurst as a convenient way to make a sustainable habit of eating a diversity of organ meats. They also have a milder braunschweiger and an even milder head cheese that gives you similar benefits, as well as a wide array of other meat products, all from animals raised on pasture. Head to grasslandbeef.com and enter promo code "Chris" at checkout to get a 15% discount on any order that is at least 7 pounds and is at least $75 after applying the discount but under 40 pounds (it can be 39.99 lbs, but not 40). You can use this discount code not once, but twice!
In this episode, you will find all of the following and more:
0:00:38 Cliff Notes
0:08:22 What is glutathione and why is it important?
0:13:33 Special Masterclass With Masterjohn Pro discount for Mastering Nutrition listeners
0:20:10 Why does glutathione survive digestion?
0:20:50 How is glutathione absorbed intact?
0:35:48 Evidence for intact absorption of glutathione
0:36:00 Oral glutathione increases tissue glutathione in animals when glutathione synthesis is blocked with BSO.
0:38:12 Glutathione crosses CACO-2 monolayers, a model of human intestinal absorption, even when glutathione breakdown is inhibited with acivicin and glutathione synthesis is inhibited with BSO.
0:39:25 Isotopically labeled glutathione fed to mice enriches labeled glutathione in liver and red blood cell with no signs of the label in glutathione digestion products.
0:40:30 Glutathione supplements increase glutathione status in humans.
0:41:10 Caveats and contrary evidence.
0:48:15 What form of supplement (sublingual, liposomal, regular) is best?
0:56:10 What are the best specific supplements?
0:58:10 What dose should you use, and how should you know if you should use it?
0:58:43 Anecdote: 1 gram of glutathione relieves laughing-induced wheezing.
1:02:50 Glutathione in foods: reduced glutathione, total glutathione, glutathione-reactive substances, net glutathione
1:08:25 Glutathione content foods is not the be-all end-all of whether a food boosts glutathione status or whether it's healthy, but it's notable and important.
Access the show notes, transcript, and comments here:
https://chrismasterjohnphd.substack.com/p/040-why-you-should-eat-glutathione
Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.
