Does Glycine or GABA Wake You Up? | Chris Masterjohn Lite #97

Does Glycine or GABA Wake You Up? | Chris Masterjohn Lite #97

Author: Chris Masterjohn, PhD December 25, 2018 Duration: 7:34

GABA and glycine supplements should both have a calming effect, helping to reduce anxiety and make you sleep better.

But some people have asked me, what if they do the opposite? What if they cause anxiety and wake you up at night? Tune in for my answer.

This episode is brought to you by Ancestral Supplements' "Living" Collagen. Our Native American ancestors believed that eating the organs from a healthy animal would support the health of the corresponding organ of the individual. Ancestral Supplements has a nose-to-tail product line of grass-fed liver, organs, "living" collagen, bone marrow and more... in the convenience of a capsule. For more information or to buy any of their products, go to https://chrismasterjohnphd.com/ancestral

This episode is brought to you by Ample. Ample is a meal-in-a-bottle that takes a total of two minutes to prepare, consume, and clean up. It provides the right balance of nutrients needed for a single meal, all from a blend of natural ingredients. Ample is available in original, vegan, and keto versions, portioned as either 400 or 600 calories per meal. I'm an advisor to Ample, and I use it to save time when I'm working on major projects on a tight schedule. Head to https://amplemeal.com and enter the promo code "CHRIS15" at checkout for a 15% discount off your first order."

To get these episodes free of ads, with transcripts, and weeks or sometimes even months before they are released to the public, along with access to monthly live Q&A sessions, sign up for the CMJ Masterpass at https://chrismasterjohnphd.com/masterpass. Use the code LITE10 to get 10% off. To make it easier to get the discount, use this link, which has the coupon already activated: https://masterpass.chrismasterjohnphd.com/cmj-masterpass/2200/buy?coupon=LITE10

Here are links to things mentioned in the episode:

Testing Nutritional Status, The Ultimate Cheat Sheet is at https://chrismasterjohnphd.com/cheatsheet (use the code LITE5 to get $5 off)

The specific comment addressed in this episode: https://chrismasterjohnphd.com/2018/10/11/dont-use-niacin-buffer-excess-methyl-groups/#comment-47351

For *many* resources on glycine: https://chrismasterjohnphd.com/methylation

On GABA, 5 Ways to Help With Glutamate Sensitivity and Glutamate Dominance: https://chrismasterjohnphd.com/2018/06/14/5-ways-help-glutamate-sensitivity-glutamate-dominance/

3 Ways to Get Enough Potassium: https://chrismasterjohnphd.com/2018/07/19/3-ways-get-enough-potassium/

The Best Way to Supplement With Potassium: https://chrismasterjohnphd.com/2018/08/14/best-way-supplement-potassium/

How to Manage Your Magnesium Status: https://chrismasterjohnphd.com/2018/08/23/manage-magnesium-status/

How to Manage Your Thiamin (Vitamin B1) Status: https://chrismasterjohnphd.com/2018/08/28/monitor-thiamin-vitamin-b1-status/

How to Manage Your Vitamin B6 Status:

https://chrismasterjohnphd.com/2018/11/13/manage-vitamin-b6-status/  

Why You Should Be Careful With Niacin and Nicotinamide Riboside: https://chrismasterjohnphd.com/2018/07/26/careful-niacin-nicotinamide-riboside/

DON'T Use Niacin to Buffer Excess Methyl Groups: https://chrismasterjohnphd.com/2018/10/11/dont-use-niacin-buffer-excess-methyl-groups/

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 712

Mastering Nutrition
Podcast Episodes
Depression Starts In Your Mitochondria [not-audio_url] [/not-audio_url]

Duration: 6:47
You could be one metabolic bottleneck away from feeling amazing. Mitome is the first at-home test that measures your cellular energy directly and gives you a personalized roadmap to optimize energy, slow aging, and prote…
Mitochondria: Why They Control Everything in Human Health [not-audio_url] [/not-audio_url]

Duration: 1:42:57
Mitochondria govern everything. Watch this with the slides here: https://www.youtube.com/watch?v=mED1_L3wZbc Mitochondria convert your food to usable energy in the form of ATP, which is used to produce, maintain, repair,…
SSRI Withdrawal Is Mitochondrial Dysfunction [not-audio_url] [/not-audio_url]

Duration: 1:29:04
Chris Masterjohn, PhD, Founder and Scientific Director of mito.me, explains why SSRI withdrawal is mitochondrial dysfunction and what to do about it. This is not medical advice, diagnosis, or treatment. 29 million Americ…
How Lactate Alkalinizes Your Muscles [not-audio_url] [/not-audio_url]

Duration: 1:34:50
For a long time, most people believed that when we exercise, our muscles make lactic acid, this acidifies the muscles, and the acidity contributes to contractile failure, fatigue, and delayed-onset muscle soreness. Some…
D-Lactate: Groundbreaking Research No One Is Talking About [not-audio_url] [/not-audio_url]

Duration: 1:30:24
D-lactate is commonly stated to be exclusively a microbial metabolite. This is found in assumptions within the medical literature for decades even when it was long-known to be false. While D-lactate is indeed made by bac…
Handling Creatine Side Effects [not-audio_url] [/not-audio_url]

Duration: 2:02
In this podcast we cover elevated creatinine, insomnia, cramps constipation, water retention, hair loss, irritation and anger, lightheadedness during lifting, bloating, aggravation of restless leg syndrome, irritation of…