Eggs, Choline Bisulfate, and TMAO | Masterjohn Q&A Files #250

Eggs, Choline Bisulfate, and TMAO | Masterjohn Q&A Files #250

Author: Chris Masterjohn, PhD August 5, 2021 Duration: 18:35

Please consider supporting my work by making a purchase using these links at one of my affiliates: https://chrismasterjohnphd.com/foursigmatic, https://chrismasterjohnphd.com/paleovalley, https://chrismasterjohnphd.com/seekinghealth, https://chrismasterjohnphd.com/ancestralsupplements, https://chrismasterjohnphd.com/magicspoon, https://chrismasterjohnphd.com/lmnt 

Plenty more at https://chrismasterjohnphd.com/support!

Question: Eggs, Choline Bisulfate, and TMAO

If you really want to know what eggs are doing to your TMAO, then I'm pretty sure Cleveland Clinic has a TMAO blood test, and that would be the best way to do it. Yeah, the Cleveland heart lab has a TMAO blood test, so you could test your response to this. If you didn't want to test, then if you assumed the worst case scenario, I would say you could probably just eat two eggs at a time and you would not raise your TMAO that much, but if you do test TMAO, you can probably show that you might be able to get away with eating six eggs at a time and not raise your TMAO that much.

But the thing is, I don't think you're going to get the same response from six eggs at a time as in that study, as you would get from eating two eggs separated and spread out from the day. And the reason is I think the TMAO is mostly generated from the choline that does not get absorbed in the small intestine, going to the colon, being available to the microbiome. So if you lower the dose of eggs and spread them out, then you should be able to kind of totally head off significant TMAO generation. 

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome


Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 712

Mastering Nutrition
Podcast Episodes
Depression Starts In Your Mitochondria [not-audio_url] [/not-audio_url]

Duration: 6:47
You could be one metabolic bottleneck away from feeling amazing. Mitome is the first at-home test that measures your cellular energy directly and gives you a personalized roadmap to optimize energy, slow aging, and prote…
Mitochondria: Why They Control Everything in Human Health [not-audio_url] [/not-audio_url]

Duration: 1:42:57
Mitochondria govern everything. Watch this with the slides here: https://www.youtube.com/watch?v=mED1_L3wZbc Mitochondria convert your food to usable energy in the form of ATP, which is used to produce, maintain, repair,…
SSRI Withdrawal Is Mitochondrial Dysfunction [not-audio_url] [/not-audio_url]

Duration: 1:29:04
Chris Masterjohn, PhD, Founder and Scientific Director of mito.me, explains why SSRI withdrawal is mitochondrial dysfunction and what to do about it. This is not medical advice, diagnosis, or treatment. 29 million Americ…
How Lactate Alkalinizes Your Muscles [not-audio_url] [/not-audio_url]

Duration: 1:34:50
For a long time, most people believed that when we exercise, our muscles make lactic acid, this acidifies the muscles, and the acidity contributes to contractile failure, fatigue, and delayed-onset muscle soreness. Some…
D-Lactate: Groundbreaking Research No One Is Talking About [not-audio_url] [/not-audio_url]

Duration: 1:30:24
D-lactate is commonly stated to be exclusively a microbial metabolite. This is found in assumptions within the medical literature for decades even when it was long-known to be false. While D-lactate is indeed made by bac…
Handling Creatine Side Effects [not-audio_url] [/not-audio_url]

Duration: 2:02
In this podcast we cover elevated creatinine, insomnia, cramps constipation, water retention, hair loss, irritation and anger, lightheadedness during lifting, bloating, aggravation of restless leg syndrome, irritation of…