How to Increase or Decrease SHBG? | Masterjohn Q&A Files #302

How to Increase or Decrease SHBG? | Masterjohn Q&A Files #302

Author: Chris Masterjohn, PhD November 14, 2022 Duration: 14:58

Short Answer: SHBG is increased by adiponectin (vitamin K2, insulin sensitivity), thyroid hormone, fasting physiology (AMPK, fat oxidation), and estrogen (especially estrone), while it is decreased by insulin resistance, obesity, the fed state and carbohydrate-dominant physiology, androgens, and polyunsaturated fat.

This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link:
 
https://chrismasterjohnphd.substack.com/p/questions-on-protein-and-longevity-1a2

In that batch of free episodes you will also find the answers to these questions:
  • Protein and Longevity
  •  Why is an IV more hydrating than salted water?

If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up:

https://chrismasterjohnphd.substack.com/qanda

Learn more about the Masterpass here:

https://chrismasterjohnphd.substack.com/about

This snippet is from the August 15, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included:

  • Does which food you eat matter when everything is digested anyway?
  • How to know if your nitric oxide is dilating your blood vessels properly?
  • How big of a problem are transient glucose spikes above 140 mg/dL?
  • Can I take too much collagen?
  • What is the maximum dose of cod liver oil safe to use long-term?
  • How much A is safe to take when I need so much to resolve my symptoms?
  • Generalizing from cell studies of green tea catechins to cups of green tea per day.
  • What to do about lumbar discs bulging?
  • Why would vitamin K2 cause a nosebleed?
  • How to balance A with D when I react poorly to D and need so much A?
  • Why would COVID decrease HRV long-term?
  • How to raise secretory IgA?
  • Rapid-fire answers to pre-submitted questions that didn't win the contest: alternatives to bone meal powder, herbal tea and nutrient absorption, retinol-binding protein, improving fat digestion, metal provocation tests, fatty liver, high-dose B vitamins, eyebrow thinning, itchy bumps after exercise, brain fog and rifaximin, low cholesterol, tolerating chlorine pools, cycling nutrients, copper toxicity, stopping supplements before blood tests, COVID vaccines causing post-nasal drip, natural vs synthetic vitamins, absorbing iron through baths, elevated EPA and DHA in RBCs, COVID affecting the vagus nerve, supplements for athletic performance, when water doesn't hydrate, tics and Tourette's, recalcitrant homocysteine, fraud and corruption in scienctific research.

    Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-august

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 712

Mastering Nutrition
Podcast Episodes
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Watch the full-length video here: https://www.youtube.com/watch?v=XhgGGbdw4zE&t=8621s Get my free 51--page report, Methylene Blue: Biohacker's Delight or Playing With Fire?, here: https://chrismasterjohnphd.substack.com/…
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Duration: 1:18:20
Get the written and referenced version here: https://chrismasterjohnphd.substack.com/p/the-guide-to-methylene-blue This is a 51-page guide in which you will learn the following: The Origin of Methylene Blue The Entry of…
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Duration: 31:04
This is now subscribers-only and is available here: https://chrismasterjohnphd.substack.com/p/why-would-citrate-or-malate-cause Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitom…
What to Do About Constipation [not-audio_url] [/not-audio_url]

Duration: 41:52
This is now subscribers-only and can be accessed here: https://chrismasterjohnphd.substack.com/p/what-to-do-about-constipation Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome…
How to slow or reverse graying of hair? | Masterjohn Q&A Files #321 [not-audio_url] [/not-audio_url]

Duration: 22:17
Question: How to slow graying of hairs and potentially reverse it? Short Answer: What works for any given individual will likely be to find the weakest link and fix it, from among the following systems: the signaling of…
How Much Iron Can We Absorb At Once? | Masterjohn Q&A Files #320 [not-audio_url] [/not-audio_url]

Duration: 28:20
Question: How much iron can we absorb at once? Short Answer: High-dose iron will produce more total absorbed iron, but will also leave more in the gut, which could cause constipation or disturb the gut microbiome. If des…