How to Increase or Decrease SHBG? | Masterjohn Q&A Files #302

How to Increase or Decrease SHBG? | Masterjohn Q&A Files #302

Author: Chris Masterjohn, PhD November 14, 2022 Duration: 14:58

Short Answer: SHBG is increased by adiponectin (vitamin K2, insulin sensitivity), thyroid hormone, fasting physiology (AMPK, fat oxidation), and estrogen (especially estrone), while it is decreased by insulin resistance, obesity, the fed state and carbohydrate-dominant physiology, androgens, and polyunsaturated fat.

This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access two other free samples using this link:
 
https://chrismasterjohnphd.substack.com/p/questions-on-protein-and-longevity-1a2

In that batch of free episodes you will also find the answers to these questions:
  • Protein and Longevity
  •  Why is an IV more hydrating than salted water?

If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up:

https://chrismasterjohnphd.substack.com/qanda

Learn more about the Masterpass here:

https://chrismasterjohnphd.substack.com/about

This snippet is from the August 15, 2022 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what's included:

  • Does which food you eat matter when everything is digested anyway?
  • How to know if your nitric oxide is dilating your blood vessels properly?
  • How big of a problem are transient glucose spikes above 140 mg/dL?
  • Can I take too much collagen?
  • What is the maximum dose of cod liver oil safe to use long-term?
  • How much A is safe to take when I need so much to resolve my symptoms?
  • Generalizing from cell studies of green tea catechins to cups of green tea per day.
  • What to do about lumbar discs bulging?
  • Why would vitamin K2 cause a nosebleed?
  • How to balance A with D when I react poorly to D and need so much A?
  • Why would COVID decrease HRV long-term?
  • How to raise secretory IgA?
  • Rapid-fire answers to pre-submitted questions that didn't win the contest: alternatives to bone meal powder, herbal tea and nutrient absorption, retinol-binding protein, improving fat digestion, metal provocation tests, fatty liver, high-dose B vitamins, eyebrow thinning, itchy bumps after exercise, brain fog and rifaximin, low cholesterol, tolerating chlorine pools, cycling nutrients, copper toxicity, stopping supplements before blood tests, COVID vaccines causing post-nasal drip, natural vs synthetic vitamins, absorbing iron through baths, elevated EPA and DHA in RBCs, COVID affecting the vagus nerve, supplements for athletic performance, when water doesn't hydrate, tics and Tourette's, recalcitrant homocysteine, fraud and corruption in scienctific research.

    Here's a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-august

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
Author: Language: English Episodes: 712

Mastering Nutrition
Podcast Episodes
Staying Immune Through the Winter [not-audio_url] [/not-audio_url]

Duration: 0:53
Get my new 7-page quick guide on how to not get sick for free when you sign up to my Substack: https://chrismasterjohnphd.substack.com/p/staying-immune-through-the-winter Chris Masterjohn, PhD, is the Founder and Scienti…
COVID Vaccine Side Effects: What Causes Them? [not-audio_url] [/not-audio_url]

Duration: 1:51:03
I am done with my work on COVID vaccines, at least until I finish my Vitamins and Minerals 101 Book, so I am now making my scientific review on the likely causes of COVID vaccine side effects public. This is an excerpt o…
Protein and Longevity | Masterjohn Q&A Files #301 [not-audio_url] [/not-audio_url]

Duration: 33:03
Short Answer: While protein restriction may have value in people with established cancer or kidney disease, cycling robustly between fasting and feeding states is likely to provide all the value that restriction of prote…
Chips! The Only Ones I'll Endorse [not-audio_url] [/not-audio_url]

Duration: 5:08
My friend Steve, who is the one who originally introduced me to the Essex Farm CSA that now supplies me with almost all my food, has invented a new tortilla chip that launches today! MASA chips are made from organic corn…
The Ancestral Health Debate [not-audio_url] [/not-audio_url]

Duration: 2:16:15
Nick Hiebert and I debate the value of ancestral health as a framework for approaching health in the modern era. For my summary of and reflections on the debate, as well as time stamps, relevant links, and a transcript,…
Mathew Crawford: Fraud in the Military's Health Database? [not-audio_url] [/not-audio_url]

Duration: 2:17:34
In this interview, Mathew Crawford walks me through his slide presentation of data showing that, at some point between 2020 and 2021, the 2016-2019 data from the US Military's health database was altered in a way that hi…