Should someone with low testosterone go back on testosterone replacement therapy or wait it out? | Masterjohn Q&A Files #107

Should someone with low testosterone go back on testosterone replacement therapy or wait it out? | Masterjohn Q&A Files #107

Author: Chris Masterjohn, PhD April 16, 2020 Duration: 8:38

Question: Should someone with low testosterone go back on testosterone replacement therapy or wait it out?

Carrie: Men have luteinizing hormone just like women do. It comes from the brain. It's what stimulates the testes to make testosterone. If you have low LH, then I know it's a brain problem, not necessarily a testicular problem. If your LH is normal, it's not in the brain.

Chris: If the question is how long should he wait, waiting is probably not going to give you any more answers than it was giving you for the last five years. Waiting probably isn't going to raise your testosterone. If you have one measurement that it's 100 in the morning and 45 in the night, you don't really know if it's increasing, like maybe six months ago it was 50. If you wanted to wait, what I would do is do some follow-up testing to see if it's actually changing over time. But if it's been flattened out for five years, I don't think it's going anywhere. But if it's been going up ten nanograms per deciliter every three months for the last five years, then you probably could wait it out. But without knowing that, there's no data indicating that waiting is a good strategy here, it sounds like.

This Q&A can also be found as part of a much longer episode, here:
https://chrismasterjohnphd.com/podcast/2019/10/19/ask-us-anything-hormones-dr-carrie-jones-may-10-2019

If you would like to be part of the next live Ask Me Anything About Nutrition, sign up for the CMJ Masterpass, which includes access to these live Zoom sessions, premium features on all my content, and hundreds of dollars of exclusive discounts. You can sign up with a 10% lifetime discount here: https://chrismasterjohnphd.com/q&a

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DISCLAIMER: I have a PhD in Nutritional Sciences and my expertise is in performing and evaluating nutritional research. I am not a medical doctor and nothing herein is medical advice.

PLEASE NOTE: As a result of the COVID-19 crisis and the time I am committing to staying on top of relevant research, as well as the high volume of questions I receive, it may take me extra time to respond to questions here. For an up-to-date list of where I respond to questions most quickly, please see the contact page on chrismasterjohnphd.com.

Access the show notes, transcript, and comments here.

Chris Masterjohn, PhD, is the Founder and Scientific Director of the mitochondria test Mitome.


Chris Masterjohn, PhD hosts Mastering Nutrition, a podcast that digs into the science of how our bodies work at a fundamental level. The focus here is on mitochondrial health-the energy powerhouses within our cells-and how optimizing them forms the cornerstone of lasting vitality. Chris brings his background as a nutrition scientist and his experience founding BioOptHealth to these conversations, which move beyond generic diet advice. Instead, the podcast explores how individual differences, informed by tools like whole genome sequencing and detailed biochemical data, can reveal personalized paths to better metabolic function. Listeners will hear deep dives into cutting-edge research, practical interpretations of complex studies, and discussions on how to apply these insights in a real-world context. This isn't about quick fixes or trending superfoods; it's about building a coherent, scientifically-grounded understanding of nutrition from the cellular level up. Each episode aims to provide the kind of nuanced, evidence-based perspective that can help you make sense of conflicting health information. Whether the topic is a specific nutrient, a metabolic pathway, or a broader principle of wellness, Chris works to translate dense science into actionable knowledge. Tune in for a thoughtful, detailed exploration of what it truly means to master your own nutritional landscape.
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