2837: The Methylene Blue Masterclass: Cutting-Edge Mitochondrial Support with Dr. Scott Sherr

2837: The Methylene Blue Masterclass: Cutting-Edge Mitochondrial Support with Dr. Scott Sherr

Author: Sal Di Stefano, Adam Schafer, Justin Andrews, Doug Egge April 16, 2026 Duration: 1:21:16

This is one of the BEST interviews we've ever done on supplements and cutting-edge supplement technology... We had Dr. Scott Sherr on the podcast — a board-certified internal medicine physician who practices health optimization medicine and hyperbaric oxygen therapy. This guy KNOWS his stuff and we break down some of the most powerful compounds you can get your hands on to improve cognitive function, athletic performance, and longevity.

Here's the reality... 94% of US adults are metabolically UNHEALTHY. That means your mitochondria — the powerhouses of your cells — are struggling to produce the energy you need. Dr. Sherr explains exactly why this happens, how it connects to everything from anxiety and depression to fat loss struggles, and what you can actually DO about it. We dive DEEP into methylene blue — the first drug ever registered with the FDA back in 1897 — and why it's become one of the most powerful tools for supporting mitochondrial function and energy production.

But it doesn't stop there... We cover the GABAergic system and why most people are walking around GABA deficient (hello anxiety, insomnia, and mood issues), the synergy between methylene blue and red light therapy, how to use these compounds for travel, and a complete sleep optimization stack that could finally get you those 90+ Oura Ring scores. If you're tired of being tired, stressed about being stressed, or just want to understand how to actually support your body at a cellular level — this episode is a MUST listen.

MAPS PPL — https://mapsppl.com (code: ppl)

SPONSORS
Troscriptions — https://troscriptions.com/mindpump (code: mindpump)
Seed — https://seed.com/mindpump (code: 25mindpump)

00:00 — Intro
5:56 — Dr. Scott Sherr's background and health optimization medicine framework
10:42 — Strengths and weaknesses of conventional vs alternative medicine
16:34 — Why 94% of US adults are metabolically unhealthy
22:30 — The 'sympathetic spiral of doom' and why doing MORE isn't better
25:48 — Deep dive into methylene blue — history and mechanisms
35:09 — MAO inhibition, serotonin syndrome risk, and dosing protocols
42:43 — Methylene blue and red light therapy synergy
48:55 — GABA system, B3-GABA, and the TroCalm formula explained
59:58 — Complete sleep optimization stack and nighttime routine
67:30 — Cordycepin benefits and immune support protocols

PEOPLE MENTIONED
Dr. Scott Sherr — Guest — board-certified internal medicine physician, health optimization medicine practitioner, co-founder of Troscriptions
Dr. Ted Achacoso — Founder of Troscriptions and the Health Optimization Medicine nonprofit, mentor to Dr. Sherr
Alan Sherr — Dr. Sherr's father — chiropractor for 45+ years who influenced his alternative medicine philosophy
Francisco Gonzalez Lima — Researcher at University of Texas Austin studying methylene blue for Alzheimer's, TBI, and stroke
Thomas DeLauer — Mutual friend who uses methylene blue 2-3 times per week on high-stress days
Paul Stamets — Referenced regarding mushroom knowledge and Amanita Muscaria/Santa Claus connection


Tired of fitness fads and conflicting advice that leaves you more confused than when you started? Mind Pump: Raw Fitness Truth cuts through the noise with a no-nonsense approach you can actually trust. Hosts Sal Di Stefano, Adam Schafer, Justin Andrews, and Doug Egge bring their combined expertise to every conversation, dismantling popular myths and calling out the pervasive snake oil in the wellness world. Instead of hype, they focus on practical, science-backed strategies for building muscle, enhancing performance, and-most importantly-sustaining long-term health. Their discussions are grounded in reality, often challenging even the most sacred institutions in the industry with a blend of sharp insight and relatable humor. Each episode of this podcast feels like an honest talk with knowledgeable friends who aren’t afraid to question everything. You’ll find clarity on nutrition, training paradigms, and lifestyle choices, all delivered without an agenda other than giving you the unfiltered facts. For anyone exhausted by the constant churn of gimmicks and seeking a sustainable path to feeling and looking better, this is an essential listen. The raw truth isn’t always pretty, but with this team guiding you, it’s undeniably effective.
Author: Language: English Episodes: 100

Mind Pump: Raw Fitness Truth
Podcast Episodes
2821: If You're Not Doing THIS You're Leaving Gains On The Table [not-audio_url] [/not-audio_url]

Duration: 1:46:11
If you're only lifting weights to build muscle… you might be leaving serious gains on the table. In this episode, the guys break down why strength training alone isn't always enough, and how adding the right forms of car…
2820: What Every Woman Needs To Know About Creatine [not-audio_url] [/not-audio_url]

Duration: 29:23
Spring Bundle Sale: https://www.mapsmarch.com/?htrafficsource=youtube-organic&hcategory=MPSHOW&el=2820 This episode is brought to you by Legion ! buylegion.com/mindpump Code "MINDPUMP" for buy one, get one 50% off for ne…
2819: You'd Look Better With MORE Body Fat [not-audio_url] [/not-audio_url]

Duration: 1:59:30
Most people think getting leaner is always better… but that's not true. In this episode, the guys break down why staying ultra-lean year-round can actually make you look worse, feel worse, and hurt your long-term health.…
2818: Beyond the Scale: Rethinking Metrics for Fitness Success [not-audio_url] [/not-audio_url]

Duration: 1:09:08
Why Daily Weigh-Ins Sabotage Progress + Drop Sets, VO2 Max, and Blue Collar Training . The hosts argue that frequent scale weigh-ins often sabotage progress because most people misinterpret weight fluctuations and let th…
2817: Should You Bulk or Cut First? (Most People Get This Wrong) [not-audio_url] [/not-audio_url]

Duration: 29:43
Should you bulk, cut, or try to recomposition your body? In this episode of the Mind Pump Podcast, Sal, Adam, and Justin break down one of the most confusing decisions in fitness: when to bulk, when to cut, and when body…
2816 : Fat Burner Supplements Are a Scam (Here's Why) [not-audio_url] [/not-audio_url]

Duration: 1:47:24
In this episode of the Mind Pump Podcast, Sal, Adam, and Justin coach live callers on fitness, training, and nutrition strategies. They open the show discussing why fat burner supplements are mostly a waste of money, the…
2814: If You Want A Lower Body Fat Percentage, Watch This ! [not-audio_url] [/not-audio_url]

Duration: 1:46:36
In this episode of Mind Pump, Sal, Adam, and Justin break down why cutting body fat isn't always the best strategy; especially for women already around 22% body fat, and explain why building muscle often produces a leane…
2813: Pilates for Aesthetics? What Actually Builds a Sculpted Body [not-audio_url] [/not-audio_url]

Duration: 1:14:50
The hosts discuss the growing popularity of Pilates and explain why it can improve movement and stability but isn't the best tool for building a sculpted physique compared to strength training. They also share stories fr…
2812: The Most Overlooked Way to Burn Fat [not-audio_url] [/not-audio_url]

Duration: 26:46
Walking might be the most underrated fat loss tool. In this episode, the hosts break down five reasons why simple daily walking can be more effective and sustainable than many traditional cardio methods. If you're trying…