2837: The Methylene Blue Masterclass: Cutting-Edge Mitochondrial Support with Dr. Scott Sherr

2837: The Methylene Blue Masterclass: Cutting-Edge Mitochondrial Support with Dr. Scott Sherr

Author: Sal Di Stefano, Adam Schafer, Justin Andrews, Doug Egge April 16, 2026 Duration: 1:21:16

This is one of the BEST interviews we've ever done on supplements and cutting-edge supplement technology... We had Dr. Scott Sherr on the podcast — a board-certified internal medicine physician who practices health optimization medicine and hyperbaric oxygen therapy. This guy KNOWS his stuff and we break down some of the most powerful compounds you can get your hands on to improve cognitive function, athletic performance, and longevity.

Here's the reality... 94% of US adults are metabolically UNHEALTHY. That means your mitochondria — the powerhouses of your cells — are struggling to produce the energy you need. Dr. Sherr explains exactly why this happens, how it connects to everything from anxiety and depression to fat loss struggles, and what you can actually DO about it. We dive DEEP into methylene blue — the first drug ever registered with the FDA back in 1897 — and why it's become one of the most powerful tools for supporting mitochondrial function and energy production.

But it doesn't stop there... We cover the GABAergic system and why most people are walking around GABA deficient (hello anxiety, insomnia, and mood issues), the synergy between methylene blue and red light therapy, how to use these compounds for travel, and a complete sleep optimization stack that could finally get you those 90+ Oura Ring scores. If you're tired of being tired, stressed about being stressed, or just want to understand how to actually support your body at a cellular level — this episode is a MUST listen.

MAPS PPL — https://mapsppl.com (code: ppl)

SPONSORS
Troscriptions — https://troscriptions.com/mindpump (code: mindpump)
Seed — https://seed.com/mindpump (code: 25mindpump)

00:00 — Intro
5:56 — Dr. Scott Sherr's background and health optimization medicine framework
10:42 — Strengths and weaknesses of conventional vs alternative medicine
16:34 — Why 94% of US adults are metabolically unhealthy
22:30 — The 'sympathetic spiral of doom' and why doing MORE isn't better
25:48 — Deep dive into methylene blue — history and mechanisms
35:09 — MAO inhibition, serotonin syndrome risk, and dosing protocols
42:43 — Methylene blue and red light therapy synergy
48:55 — GABA system, B3-GABA, and the TroCalm formula explained
59:58 — Complete sleep optimization stack and nighttime routine
67:30 — Cordycepin benefits and immune support protocols

PEOPLE MENTIONED
Dr. Scott Sherr — Guest — board-certified internal medicine physician, health optimization medicine practitioner, co-founder of Troscriptions
Dr. Ted Achacoso — Founder of Troscriptions and the Health Optimization Medicine nonprofit, mentor to Dr. Sherr
Alan Sherr — Dr. Sherr's father — chiropractor for 45+ years who influenced his alternative medicine philosophy
Francisco Gonzalez Lima — Researcher at University of Texas Austin studying methylene blue for Alzheimer's, TBI, and stroke
Thomas DeLauer — Mutual friend who uses methylene blue 2-3 times per week on high-stress days
Paul Stamets — Referenced regarding mushroom knowledge and Amanita Muscaria/Santa Claus connection


Tired of fitness fads and conflicting advice that leaves you more confused than when you started? Mind Pump: Raw Fitness Truth cuts through the noise with a no-nonsense approach you can actually trust. Hosts Sal Di Stefano, Adam Schafer, Justin Andrews, and Doug Egge bring their combined expertise to every conversation, dismantling popular myths and calling out the pervasive snake oil in the wellness world. Instead of hype, they focus on practical, science-backed strategies for building muscle, enhancing performance, and-most importantly-sustaining long-term health. Their discussions are grounded in reality, often challenging even the most sacred institutions in the industry with a blend of sharp insight and relatable humor. Each episode of this podcast feels like an honest talk with knowledgeable friends who aren’t afraid to question everything. You’ll find clarity on nutrition, training paradigms, and lifestyle choices, all delivered without an agenda other than giving you the unfiltered facts. For anyone exhausted by the constant churn of gimmicks and seeking a sustainable path to feeling and looking better, this is an essential listen. The raw truth isn’t always pretty, but with this team guiding you, it’s undeniably effective.
Author: Language: English Episodes: 100

Mind Pump: Raw Fitness Truth
Podcast Episodes
2811: This Food Item IS NOT As Healthy as You Think [not-audio_url] [/not-audio_url]

Duration: 1:52:38
Blended fruit smoothies are often marketed as healthy, but the hosts explain why they can actually sabotage fat loss by spiking blood sugar, reducing satiety, and making it easy to overconsume calories. The conversation…
2810: Why January Fitness Resolutions Fail [not-audio_url] [/not-audio_url]

Duration: 27:28
Why Most January Transformations Fail Success isn't losing weight; it's keeping it off for the rest of your life. (1:56) 5 Reasons Why Most January Transformations Fail 1. People set the wrong goal. (5:09) 2. People will…
2809 : Is Cardio Ideal For Fat Loss? [not-audio_url] [/not-audio_url]

Duration: 2:02:03
Mind Pump Fit Tip: Cardio is Good for Fat Loss for 2-3 weeks. After that, it is a Waste of Time! (2:00) 1-minute cardio strategy. (21:58) I do not want to work out with you. (31:05) An INSANE commercial for fat-loss. (33…
2808: Build a Butt or Get Abs? Where Do I Start? [not-audio_url] [/not-audio_url]

Duration: 1:15:17
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2807: Secrets To Extreme Butt Growth [not-audio_url] [/not-audio_url]

Duration: 20:57
Glute Building Masterclass LIVE Glute Building Masterclass by Mind Pump top-trainer Corinne. Sign up today! (1:50) How we got here. (3:11) Breaking down the components of the barbell squat. (3:59) The importance of havin…
2805: How To Know When It's The Right Time To Cut [not-audio_url] [/not-audio_url]

Duration: 27:43
How To Know When It's Time to Cut The #1 reason why people CONSISTENTLY fail. (1:46) What does it mean to go on a cut? (4:01) The definition of a successful cut. (4:22) The reasons you should NOT go on a cut. 1. When you…
2804: The Ultimate At-Home Dumbbell ONLY Workout [not-audio_url] [/not-audio_url]

Duration: 1:38:00
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2803: The Lifestyle Factors That Make or Break Results [not-audio_url] [/not-audio_url]

Duration: 1:06:57
Mind Pump Fit Tip: How much of an impact do these 5 things really have on your health & fitness goals? (2:15) Cardio life for Sal. (26:30) Why you need a sleep routine, not a morning routine. (30:34) The importance of da…