Encore Episode: Exploring Endogenous DMT with Rick Strassman, MD

Encore Episode: Exploring Endogenous DMT with Rick Strassman, MD

Author: Lynn Marie Morski, MD, JD September 17, 2025 Duration: 52:41

In this episode of the Psychedelic Medicine Podcast, Rick Strassman, MD joins to discuss the topic of endogenous DMT. Dr. Strassman is adjunct associate professor of psychiatry at the University of New Mexico in Albuquerque and author of DMT: The Spirit Molecule and The Psychedelic Handbook. His DMT and psilocybin studies in the early 1990s initiated the renewal of human research with psychedelics in the U.S.

In this conversation, Dr. Strassman discusses the finer details of DMT, from endogenous production in humans and animals, to visionary experiences and theological implications. Dr. Strassman also covers the research that's been done regarding endogenous DMT, clarifying what we do and don't know about the role of the pineal gland and how this might relate to what is reported during near-death experiences. He also discusses the personal and relational quality of psychedelic experiences induced by DMT, mentioning that unitive mystical experiences were actually rare in the trials he conducted, with more experiences having a personal quality, drawing upon the life experiences and interests of the participants. In closing, Dr. Strassman shares his thoughts on the origins of the visions that many report during DMT use. 

 

In this episode you'll hear:

  • The overlap between psychedelic experiences and meditation techniques
  • The relationship between fear, self-awareness, and difficult DMT experiences
  • The placebo effect and psychedelic research
  • Dr. Strassman's thoughts on non-hallucinogenic psychedelics
  • DMT as a possible treatment for strokes to prevent damage and speed recovery
  • Effects of microdosing in animals and humans

 

Quotes:

"I think the best term for these compounds is psychedelic, which means mind manifesting or mind disclosing, because only one of our fifty-five or so normal volunteers had what one might call a mystical unitive state. … Everybody basically had an experience that was totally dependent on them. It was not inherent in the drug." [9:45]

"You could still speculate that to the extent that non-drug states resemble those brought on by giving DMT… that DMT plays a role in the production of those states. But the data aren't there yet. That's why we need more people doing this research." [24:16]

"If psychedelics are super placebos and if we have a psychedelic drug in our brain, it's attempting to speculate that normally the placebo effect could be mediated by endogenous DMT." [27:42]

"If you starve neurons of oxygen they start dying, but if you add DMT they survive much longer. So there seems to be some neuroprotective effect of DMT on ischemic damage to neurons, at least in the test tube." [32:27]

 

Links:

Dr. Strassman's website

The Psychedelic Handbook by Dr. Strassman

DMT: The Spirit Molecule by Dr. Strassman

DMT and the Soul of Prophecy: A New Science of Spiritual Revelation in the Hebrew Bible by Dr. Strassman

Dr. Strassman on Facebook
Previous episode: Exploring DMT Entities with Matthew Johnson, PhD

Psychedelic Medicine Association

Porangui


Exploring the frontier of mind and medicine, the Psychedelic Medicine Podcast with Dr. Lynn Marie Morski delves into the complex world of psychedelic substances and their potential to heal. Hosted by Lynn Marie Morski, a physician and attorney, this podcast navigates the intricate intersection of cutting-edge science, clinical practice, and evolving policy. Each episode brings a grounded, expert perspective to conversations about psilocybin, MDMA, ketamine, LSD, ayahuasca, ibogaine, and other compounds, moving beyond hype to examine the real-world implications of this therapeutic renaissance. Listeners will hear detailed discussions on the latest peer-reviewed research, practical insights from medical professionals integrating these approaches, and thoughtful analysis of the legal landscape shaping access. The dialogue is rooted in a commitment to safety, ethics, and evidence, offering a clear-eyed look at both the profound promise and the challenges inherent in psychedelic medicine. Whether you're a healthcare provider, a patient, a researcher, or simply intellectually curious, this podcast provides an essential, nuanced resource for understanding how these ancient and modern substances are reshaping perspectives on mental health, consciousness, and treatment. It’s a space for serious inquiry, where complex questions about healing, neuroscience, and society are met with informed, accessible conversation.
Author: Language: English Episodes: 50

Psychedelic Medicine Podcast with Dr. Lynn Marie Morski
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