What We Got Wrong About GLP-1s (And What's Right) | Dr. Tyna Moore
Author: Dr. Mark Hyman
August 12, 2026
Duration: 1:18:20
GLP-1 medications have changed how we treat obesity and metabolic disease. But as their use has exploded, so have questions about side effects, muscle loss, long-term use, and whether patients are receiving the support they need to use them safely.
In this episode, I reconnect with metabolic health and regenerative medicine expert Dr. Tyna Moore to revisit our conversation from two years ago and examine what we’ve learned since.
We discuss:
How to tell when your GLP-1 dose may be too high
What you can do to protect your muscle and bone during weight loss
Which metabolic and nutritional markers should you check before and during treatment
Why weight can sometimes return after stopping a GLP-1
What emerging research suggests about GLP-1s beyond weight loss
GLP-1s can be life-changing, but a lower number on the scale isn’t the same as better health. Ultimately, how these medications are used—from dosing and monitoring to nutrition and strength training—matters just as much as whether they’re used at all.
Additional resources:
Join Dr. Tyna Moore’s community
Listen to Dr. Tyna Moore’s previous appearance on The Dr. Hyman Show
View Show Notes From This Episode
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(0:00) Introduction, Dr. Hyman's evolving views, and episode goals
(0:43) Sponsor: Rose Nutrition Liposomal NAD
(1:42) Sponsor: Seatopia clean seafood box
(2:44) Disclaimers and Lyme disease preview
(4:04) Guest Dr. Tina Moore reintroduced
(4:30) GLP-1s: Effects after years and microdosing strategies
(7:14) Risks of high-dose GLP-1s and misconceptions about muscle/bone loss
(13:09) Functional deficiencies and microdosing approaches
(17:05) Sponsor: Made In stainless clad cookware
(18:02) Sponsor: Timeline with Mitopure
(18:58) Broader and additional benefits of metabolic health and GLP-1s
(21:48) GLP-1s for immune and brain health; genetic differences
(27:59) Introduction to peptides and GLP-1 drugs
(32:36) Gray market concerns and weight regain after stopping GLP-1s
(37:14) Long-term safety, cost, and personalizing GLP-1 treatment
(40:57) Emotional blunting and recent concerns about GLP-1s
(46:30) Functional medicine approach: addressing root causes
(46:46) Sponsor: Sunlighten Sauna
(47:20) Sponsor: Magnesium Breakthrough from Bio Optimizers
(48:17) Dr. Hyman’s evolving perspective on GLP-1s
(49:19) Hormonal effects of GLP-1s for men and women
(55:02) Baseline lab markers and tests before GLP-1s
(57:10) New and next-gen GLP-1 therapies
(59:43) Telemedicine, gray market issues, and importance of reputable practitioners
(1:05:57) Rapid fire: Alcohol, common mistakes, misconceptions, and eligibility for GLP-1s
(1:08:16) Key lab tests and surprising non-weight benefits
