AP De Silva on building molecular fluorescence sensors for healthcare

AP De Silva on building molecular fluorescence sensors for healthcare

Author: BBC Radio 4 November 18, 2025 Duration: 28:11

From humble beginnings in his native Sri Lanka, to a more than 40 year academic career at Queen’s University Belfast, Prof. AP (Amilra Prasanna) De Silva’s research into molecular photosensors has led to a pioneering career in that’s evolved from chemistry to medical diagnostics on one hand, to information processing on the other.

Prof. De Silva challenged cultural expectations and overcame the lack of opportunities in chemistry that were available in Sri Lanka in the early 1970s. He first moved to Belfast to pursue research in photochemistry at Queen’s University. Inspired by his grandmother’s struggle with high blood pressure he engineered a unique sodium photosensor by marrying fluorescent molecules with chemical receptors. As a result of his international collaborations, a commercial, portable sensor was developed to detect salts and minerals in the blood. Its speed of analysis has since saved countless lives and improved healthcare around the world.

AP talks to Jim Al-Khalili about his passion for engineering molecules and how his photochemical innovations have since crossed into computer science. They’ve been developed to perform molecular computations far inside the human body - where silicon microchips fear to tread. A new deeper understanding of life inside our tissues and cells beckons.

Presented by Jim Al-Khalili Produced by Adrian Washbourne Executive Producer: Alexandra Feachem A BBC Studios Production


Hosted by physicist and author Professor Jim Al-Khalili, The Life Scientific offers a rare and intimate glimpse into the minds shaping our world. Each conversation moves beyond the standard lecture or interview, weaving together personal history with groundbreaking ideas. You’ll hear how childhood curiosity, unexpected setbacks, and moments of sheer luck have steered the careers of some of today's most influential researchers. This BBC Radio 4 podcast treats science not as a remote collection of facts, but as a deeply human endeavor driven by passion, perseverance, and sometimes, serendipity. The discussions delve into the real process of discovery-the late-night frustrations, the collaborative breakthroughs, and the ethical questions that arise from new knowledge. While exploring everything from the smallest particles to the vastness of the cosmos, the core of each episode remains the individual behind the science. Listeners come to understand not just what these scientists know, but who they are and what continues to drive them forward. It’s a series that connects the personal to the universal, making complex fields accessible and profoundly relevant. By focusing on the life as much as the science, this podcast reveals how our future is being built, one question at a time, in labs, field stations, and offices around the globe.
Author: Language: English Episodes: 50

The Life Scientific
Podcast Episodes
Pierre Friedlingstein on carbon’s pivotal role in climate change [not-audio_url] [/not-audio_url]

Duration: 28:10
The COP30 climate summit is taking place in the Brazilian city of Belém, a gateway to the Amazon rainforest, which continues to face widespread deforestation. We all know that our climate is changing and that we are larg…
Julia Simner on tasty words and hearing colours [not-audio_url] [/not-audio_url]

Duration: 28:22
Imagine if you were listening to an opera or a Taylor Swift concert, and as the lights in the auditorium dimmed, the music was accompanied by a rainbow of colours only you could see. Perhaps while listening to your frien…
Caroline Smith on meteorites and potential ancient life on Mars [not-audio_url] [/not-audio_url]

Duration: 28:24
Caroline Smith is passionate about space rocks, whether they’re samples collected from the surface of asteroids and the Moon and hopefully Mars one day soon, or meteorites, those alien rock fragments that have survived t…
Peter Knight on quantum technologies [not-audio_url] [/not-audio_url]

Duration: 28:09
There are problems and tasks so hard and complicated that it would take today’s most powerful supercomputers millions of years to crack them. But in the next decade, we may well have quantum computers which could solve s…
Eleanor Schofield on conserving Tudor warship the Mary Rose [not-audio_url] [/not-audio_url]

Duration: 28:20
In July 1545, King Henry VIII watched from Southsea Castle on England's south coast as his fleet sailed out to face the French - only to witness his prized warship, the Mary Rose, sink before his eyes. Raised from the So…
Gareth Collett on a career in bomb disposal [not-audio_url] [/not-audio_url]

Duration: 28:29
Movies might have us believe that bomb disposal comes down to cutting the right wire. In fact, explosive devices are complex and varied - and learning how to dispose of them safely involves intense training, as well as t…
Sonia Gandhi on building model brains to tackle Parkinson’s disease [not-audio_url] [/not-audio_url]

Duration: 28:23
Many people will be familiar with Parkinson’s disease: the progressive brain disorder that causes symptoms including tremors and slower movement, leading on to serious cognitive problems. You might not know that it’s the…
Mark O'Shea on close encounters with venomous snakes [not-audio_url] [/not-audio_url]

Duration: 28:28
How do you feel about snakes? What about highly venomous ones?For Mark O’Shea, close encounters with the world’s most rare and deadly snakes are not only his profession, but his passion. Mark is a Professor of Herpetolog…
Kevin Fong on medical planning for Mars and Earth-based emergencies [not-audio_url] [/not-audio_url]

Duration: 28:39
There can't be many people in the world who've saved lives in hospital emergency rooms and also helped care for the wellbeing of astronauts in space – but Kevin Fong’s career has followed a singular path: from astrophysi…