AP De Silva on building molecular fluorescence sensors for healthcare

AP De Silva on building molecular fluorescence sensors for healthcare

Author: BBC Radio 4 November 18, 2025 Duration: 28:11

From humble beginnings in his native Sri Lanka, to a more than 40 year academic career at Queen’s University Belfast, Prof. AP (Amilra Prasanna) De Silva’s research into molecular photosensors has led to a pioneering career in that’s evolved from chemistry to medical diagnostics on one hand, to information processing on the other.

Prof. De Silva challenged cultural expectations and overcame the lack of opportunities in chemistry that were available in Sri Lanka in the early 1970s. He first moved to Belfast to pursue research in photochemistry at Queen’s University. Inspired by his grandmother’s struggle with high blood pressure he engineered a unique sodium photosensor by marrying fluorescent molecules with chemical receptors. As a result of his international collaborations, a commercial, portable sensor was developed to detect salts and minerals in the blood. Its speed of analysis has since saved countless lives and improved healthcare around the world.

AP talks to Jim Al-Khalili about his passion for engineering molecules and how his photochemical innovations have since crossed into computer science. They’ve been developed to perform molecular computations far inside the human body - where silicon microchips fear to tread. A new deeper understanding of life inside our tissues and cells beckons.

Presented by Jim Al-Khalili Produced by Adrian Washbourne Executive Producer: Alexandra Feachem A BBC Studios Production


Hosted by physicist and author Professor Jim Al-Khalili, The Life Scientific offers a rare and intimate glimpse into the minds shaping our world. Each conversation moves beyond the standard lecture or interview, weaving together personal history with groundbreaking ideas. You’ll hear how childhood curiosity, unexpected setbacks, and moments of sheer luck have steered the careers of some of today's most influential researchers. This BBC Radio 4 podcast treats science not as a remote collection of facts, but as a deeply human endeavor driven by passion, perseverance, and sometimes, serendipity. The discussions delve into the real process of discovery-the late-night frustrations, the collaborative breakthroughs, and the ethical questions that arise from new knowledge. While exploring everything from the smallest particles to the vastness of the cosmos, the core of each episode remains the individual behind the science. Listeners come to understand not just what these scientists know, but who they are and what continues to drive them forward. It’s a series that connects the personal to the universal, making complex fields accessible and profoundly relevant. By focusing on the life as much as the science, this podcast reveals how our future is being built, one question at a time, in labs, field stations, and offices around the globe.
Author: Language: English Episodes: 50

The Life Scientific
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