#233 The Science of Hunger: GLP-1, Appetite Control & Natural Weight Management With Sarah Kennedy

#233 The Science of Hunger: GLP-1, Appetite Control & Natural Weight Management With Sarah Kennedy

Author: Claudia von Boeselager January 8, 2026 Duration: 34:30
Why does hunger feel so loud — and why does willpower so often fail? In this illuminating episode, Sarah Kennedy, founder and CEO of Calocurb, unpacks the biology of hunger, the gut-brain axis, and the powerful role of GLP-1 in appetite regulation. Drawing on over 15 years and $30 million of New Zealand government-backed science, Sarah explains why hunger is driven by our most primitive brain systems — and how understanding this biology can finally bring peace with food. We explore how bitter taste receptors in the gut stimulate appetite-suppressing hormones, why dieting can actually increase hunger over time, and how natural GLP-1 activation differs fundamentally from pharmaceutical injections like Ozempic. We explore: - The evolutionary biology of hunger and food noise - How GLP-1, CCK and PYY regulate appetite - Why calorie restriction backfires long-term - Natural vs synthetic GLP-1 pathways - How appetite regulation supports metabolic health, insulin sensitivity & longevity This is a science-grounded, compassionate conversation that reframes hunger — not as a personal failure, but as biology you can finally work with. This episode was brought to you by: - Calocurb

Hosted by Claudia von Boeselager, The Longevity & Lifestyle Podcast moves beyond simple health tips to explore a more integrated vision of well-being. Each conversation focuses on practical, often overlooked strategies drawn from pioneering experts across various fields. The aim is to provide listeners with tangible tools and perspectives that contribute to a longer, more vibrant life, framing personal health as the foundation for greater impact. This isn't just about adding years; it's about enriching the quality of every day, examining how daily choices in fitness, mindset, and self-improvement collectively shape our potential. Claudia's approach is grounded in empowerment, offering a blend of alternative and mainstream wisdom to help you craft a resilient and optimized lifestyle. You'll hear detailed discussions on applying these principles in realistic ways, breaking down complex ideas into actionable steps. The podcast serves as a dedicated space for anyone looking to thoughtfully upgrade their habits and outlook, driven by a mission to make holistic health knowledge accessible and actionable. Tune in for a deep, nuanced exploration of what it truly means to live at your best, discovering how refined daily practices can extend your healthspan and amplify your capacity to contribute positively to the world around you.
Author: Language: English Episodes: 100

The Longevity & Lifestyle Podcast
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