China Kills Meta / Manus Deal (Story Of The Year) | E2281

China Kills Meta / Manus Deal (Story Of The Year) | E2281

Author: Jason Calacanis April 28, 2026 Duration: 53:03


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What’s the technology story of the year? No, it’s not Anthropic’s Mythos model, nor any other AI model. Upcoming IPOs? Wrong again. Jason thinks it’s China’s government’s decision to block Meta's acquisition of Manus. The multi-billion-dollar deal was heralded as evidence that AI companies founded in China could sidestep onerous government meddling by moving their operations to Singapore. That loophole now appears closed.

Jason and Lon then dug into the newly-reforged OpenAI-Microsoft partnership. The two companies have had a mutually beneficial, if fractious, operating relationship to date; that they had to rework their agreement is not a shock.

Then, your hosts watched and digested a video from China purportedly showing a self-driving car hitting a child at speed. What would happen in the United States if such a tragedy struck? And is that fait accompli?

Closing the show, Jason and Lon reacted to the latest Russell Brand implosion, discussed Lon’s new favorite show ‘Criminal Record,’ and shared recommended foot pedals (for AI dictation) and headphones for the road warriors tuning in.

Key Links: OpenAI and Microsoft

OpenAI’s announcement of its new Microsoft deal

Microsoft’s announcement of its new OpenAI deal

OpenAI announces its deal with AWS

News that Microsoft was considering legal action against OpenAI

Microsoft-OpenAI negotiations late 2025 edition, and terms announced in early 2026

Amazon announces that OpenAI models are coming to AWS



Timestamps:

0:00 Show starts

1:24 OpenAI and Microsoft have a new deal

3:22 Why would Microsoft cede exclusive access to OpenAI models?

5:36 Plaud: If your work depends on conversations — interviews, meetings, calls — you need a Plaud NotePin. You can check it out at https://Plaud.ai/twist and use code TWIST for 10% off!

8:09 Why Jason thinks Microsoft and Apple should work together on AI

9:45 China will block the Meta-Manus deal

12:12 Deel - Founders scale faster on Deel. Set up payroll for any country in minutes, hire anyone anywhere, get visas handled fast, and get back to building. Visit https://deel.com/twist to learn more.

12:23 Golden Shares and what they provide

14:57 How do you unravel a multi-billion-dollar deal?

22:08 Sentry - New users can get $240 in free credits when they go to https://sentry.io/twist and use the code TWIST

24:42 The Huawei ADC crash

29:49 What happens when something similar happens in the United States?

31:55 IM8 Health: Start feeling like your best self every day. Go to https://IM8health.com/twist and use the code TWiST to get a free welcome kit, five free travel sachets, and 10% off your order.

36:15 Russell Brand's public humiliation

41:22 Don't trust palm reading!

43:59 Lon's Off Duty streaming pick: Criminal Record

46:25 Jason's Pick: Which foot pedal for AI dictation is right for you?

48:43 Jason's Pick: In the market for new headphones?

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Every week, Jason Calacanis dives headfirst into the swirling vortex of Silicon Valley and global tech with This Week in Startups. It’s a direct line to the conversations shaping our digital future, moving far beyond surface-level news. You’ll hear Jason’s unfiltered analysis on everything from market shifts and media trends to the underlying mechanics of building a business, all delivered with a blend of enthusiasm and seasoned skepticism. The core of this podcast, however, lies in the guests. Jason sits down with the very people driving change-founders who have scaled impossible heights, operators managing daily chaos, and investors who spot trends before they become obvious. These conversations are less like formal interviews and more like insider debriefs, pulling back the curtain on real strategies, painful failures, and unexpected successes. For anyone curious about how technology is built, funded, and ultimately changes the world, this series offers a front-row seat. It’s the context behind the headlines, providing a deeper understanding of the forces at play in startups and technology. Tune in for a consistently engaging and insightful look at the ecosystem, straight from someone who lives and breathes it.
Author: Language: en-us Episodes: 100

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