The hottest running app has nothing to do with speed | E2303

The hottest running app has nothing to do with speed | E2303

Author: Jason Calacanis June 23, 2026 Duration: 1:03:04
This Week In Startups is made possible by:Agree - https://agree.comQuo - https://quo.com/TWiSTSuperhuman - https://superhuman.comToday's show:In this double-header, Jason and Lon chat with Louis Phillips, founder of the gamified running app INTVL, which turns a quick job around the block into a worldwide turf war competition. Find out how he grew the app to over 1 million downloads without any paid ads, just making videos from his home office.PLUS Alex sits down with Alice Zhang, CEO of Verge Labs, which pivoted from making drugs to building the AI infrastructure that helps pharma companies develop their own treatments. Find out how they accumulated one of the world's largest proprietary brain datasets and why brain tissue is the "LiDAR of neuroscience."Guests:INTVL: https://www.intvl.com.au/INTVL on Instagram: https://www.instagram.com/intvl.appLouis Phillips on Instagram: https://www.instagram.com/louisphillips12Verge Labs: https://vergelabs.com/Alice Zhang on X: https://x.com/AliceXinliZhangRelevant LinksMeta's Ad Library: https://www.facebook.com/ads/library/Strava: https://www.strava.com/Pokémon Go: https://pokemongo.com/Fitbod: https://fitbod.me/Tonebase: https://www.tonebase.co/Calm: https://www.calm.com/Hamilton Island official site: https://www.hamiltonisland.com.au/"Mr. Inbetween" trailer: https://www.youtube.com/watch?v=EooRG3QhQOYArticle: "Verge Genomics Rebrands as Verge Labs": https://trial.medpath.com/news/verge-genomics-rebrands-as-verge-labs-following-als-drug-trial-failure-pivots-to-ai-driven-target-discoveryEli Lilly: https://www.lilly.com/Chai Discovery: https://www.chaidiscovery.com/Noetik: https://www.noetik.ai/Tempus: https://www.tempus.com/Timestamps:0:00 Louis on building in Melbourne, Australia 7:44 Why INTVL ignores how fast you run 9:59 Agree - Stop chasing invoices at https://agree.com and tell them Jason sent you to get 50% off for life! 15:52 Using gamification for good 19:10 Powering INTVL's impressive growth 19:55 Quo (formerly OpenPhone) - Quo gives you a clean, modern way to handle every customer call, text, and thread all in one place. Try it free at https://quo.com/TWiST 26:16 The future of TWiST Australia 27:14 Will AI ever cure cancer? 27:54 Inside Verge's rebrand 30:31 Superhuman - Get AI that works where you work. Unlock your Superhuman potential at https://superhuman.com 32:01 Brain tissue as "ground truth" 36:01 Why brain tissue is so valuable as data 43:52 Verge's Eli Lilly partnership 51:34 "You're going to tell me when I'm going to die" 56:11 How AI could impact drug prices 58:19 Clinical trial FAILS and how to move onSubscribe to the TWiST500 newsletter: https://ticker.thisweekinstartups.comCheck out the TWIST500: https://www.twist500.comSubscribe to This Week in Startups on Apple: https://rb.gy/v19fcpFollow Lon:X: https://x.com/lonsFollow Alex:X: https://x.com/alexLinkedIn: ⁠https://www.linkedin.com/in/alexwilhelmFollow Jason:X: https://twitter.com/JasonLinkedIn: https://www.linkedin.com/in/jasoncalacanisCheck out all our partner offers: https://partners.launch.co/Great TWIST interviews: Will Guidara, Eoghan McCabe, Steve Huffman, Brian Chesky, Bob Moesta, Aaron Levie, Sophia Amoruso, Reid Hoffman, Frank Slootman, Billy McFarlandCheck out Jason's suite of newsletters: https://substack.com/@calacanisFollow TWiST:Twitter: https://twitter.com/TWiStartupsYouTube: https://www.youtube.com/thisweekinInstagram: https://www.instagram.com/thisweekinstartupsTikTok: https://www.tiktok.com/@thisweekinstartupsSubstack: https://twistartups.substack.com

Every week, Jason Calacanis dives headfirst into the swirling vortex of Silicon Valley and global tech with This Week in Startups. It’s a direct line to the conversations shaping our digital future, moving far beyond surface-level news. You’ll hear Jason’s unfiltered analysis on everything from market shifts and media trends to the underlying mechanics of building a business, all delivered with a blend of enthusiasm and seasoned skepticism. The core of this podcast, however, lies in the guests. Jason sits down with the very people driving change-founders who have scaled impossible heights, operators managing daily chaos, and investors who spot trends before they become obvious. These conversations are less like formal interviews and more like insider debriefs, pulling back the curtain on real strategies, painful failures, and unexpected successes. For anyone curious about how technology is built, funded, and ultimately changes the world, this series offers a front-row seat. It’s the context behind the headlines, providing a deeper understanding of the forces at play in startups and technology. Tune in for a consistently engaging and insightful look at the ecosystem, straight from someone who lives and breathes it.
Author: Language: en-us Episodes: 50

This Week in Startups
Podcast Episodes
The Startup Building the First Hotel on the Moon… [not-audio_url] [/not-audio_url]

Duration: 1:40:54
This Week In Startups is made possible by: Every.io - visit every.io Sentry.io - sentry.io/twist Vanta - vanta.com/twist Today's show: The next SpaceX won't be building rockets; it'll build the first hotel on the Moon. T…
SpaceX IPO Day: What Wall St. and the media missed | E2300 [not-audio_url] [/not-audio_url]

Duration: 1:19:56
This Week In Startups is made possible by: Plaud https://Plaud.ai/twist Pilot https://pilot.com/twist Agree https://agree.com IM8 Health https://IM8health.com/twist After watching Elon build out his rocket (and AI) compa…
Why the most expensive Seed deals are the cheapest | E2299 [not-audio_url] [/not-audio_url]

Duration: 1:08:23
This Week In Startups is made possible by: NetSuite - Netsuite.com/TWiST Deel - Deel.com/TWiST Squarespace - Squarespace.com/TWiST Two days before SpaceX launches the largest IPO in history at a flat $135/share, our VC r…
The AI Tutor That Makes Kids Actually Think | E2298 [not-audio_url] [/not-audio_url]

Duration: 1:00:19
The AI Tutor That Makes Kids Actually Think | E2298 This Week In Startups is made possible by: Northwest Registered Agent https://northwestregisteredagent.com/twist LinkedIn Jobs https://LinkedIn.com/twist Shopify https:…
The project SpaceX's first employee raised $500M for [not-audio_url] [/not-audio_url]

Duration: 1:01:36
This Week In Startups is made possible by: Northwest Registered Agent - NorthwestRegistereAagent.com/TWIST Every - Every.io Sentry - Sentry.io/TWIST Today's show: Want to get to space? Several launch companies can help y…
This Startup Fused Human Brain Cells with Silicon Chips | E2295 [not-audio_url] [/not-audio_url]

Duration: 1:06:16
This Week In Startups is made possible by: Deel https://deel.com/twist Quo https://quo.com/TWiST LinkedIn Jobs https://LinkedIn.com/twist Today's show: Cortical Labs is the world's first company selling biological comput…
How to Raise a Seed Round in 2026: Ask Jason | E2294 [not-audio_url] [/not-audio_url]

Duration: 57:55
This Week In Startups is made possible by: Grasshopper Bank https://grasshopper.bank/twistLinkedIn Jobs https://LinkedIn.com/twistNorthwest Registered Agent https://northwestregisteredagent.com/twist Today's show: Jason…
The Drone Company Quietly Taking Over Delivery [not-audio_url] [/not-audio_url]

Duration: 1:01:23
This Week In Startups is made possible by: Render - render.com/twist Deel - deel.com/twist Northwest Registered Agent - northwestregisteredagent.com/twist Today's show: The "Ryanair of drone delivery" just raised $50 mil…