How Understanding Your Brain Chemistry Can Change Your Life

How Understanding Your Brain Chemistry Can Change Your Life

Author: Zak Rosen April 22, 2026 Duration: 20:28
Mike Pesca is the creator and host of The Gist, the longest-running daily news podcast in history, moderator of Not Even Mad, a political debate podcast, and host of Funny You Should Mention, a co-production with the Comedy Cellar, where he conducts in-depth interviews with stand up comedians. On today's show we get into how understanding your own neurochemistry can offer new perspectives on mental health and anxiety. READ: Opinion | The Feel-Good Gene LISTEN: How to address acute anxiety with Terry Rawls --- LISTEN: You in Mind |Yoni London --- LISTEN TO WH ad-free by becoming a Patron today! WH MERCH IS HERE!!!!!!!! Learn more about your ad choices. Visit megaphone.fm/adchoices

Hosted by Zak Rosen, Weirdly Helpful (which you might remember as The Best Advice Show) operates on a simple, charming premise: the most effective strategies for getting through the day aren't always the most obvious ones. This is a weekly, compact podcast built on the idea that a slight shift in perspective or a deliberately odd action can recalibrate your mood or solve a stubborn problem. Each episode features a different guest contributor sharing one specific, curious tactic they personally use. You won't get lengthy lectures or clinical self-help here. Instead, you'll hear about tangible, often playful experiments and rituals-think of it as a friendly, audio-based swap meet for life hacks that are delightfully left of center. The practices discussed are genuinely unconventional, yet presented with such warmth and clarity that their utility becomes undeniable. It’s that moment of surprised recognition when something seemingly bizarre, like vocalizing frustration in a primal way or transforming a daily routine into a small sensory celebration, clicks into place as profoundly sensible. The podcast lives in the intersection of Education, Fitness, and Mental Health precisely because improving daily life touches all those facets. Rosen curates these conversations to be short bursts of inspiration, leaving you with a single, actionable idea to sit with and perhaps try for yourself, wondering why you hadn't thought of it before. The cumulative effect of listening is a gentle expansion of what you consider helpful, finding value and a bit of magic in the wonderfully strange.
Author: Language: English Episodes: 50

Weirdly Helpful (formerly The Best Advice Show)
Podcast Episodes
Let's Meet at the Corner of Mindfulness and Playfulness [not-audio_url] [/not-audio_url]

Duration: 13:05
Zak's Weirdly Helpful guru, Laura Hawley, returns to the show to share a transcendent and fun gift-giving practice. Hear Laura on howling and bus art. BECOME A WEIRD HELPER and GET AD-FREE EPISODES @ https://www.patreon.…
The Weirdly Helpful Gratitude Hour [not-audio_url] [/not-audio_url]

Duration: 13:38
Weirdly Helpful advice on today's episode comes from Lainey, Margo, Rabbi Yoni and Zak! --- If you have a response to Morty's voice memo, send me something at Zak@weirdlyhelpful.show or call the hotline @ 844-935-2378 --…
What's the Deal with Handshaking in 2025? [not-audio_url] [/not-audio_url]

Duration: 13:01
Lizzie Post is the great-great-granddaughter of Emily Post, and author of Emily Post's Etiquette - The Centennial Edition, and Higher Etiquette, as well as Emily Post’s Wedding Etiquette 6th edition, and The Etiquette Ad…
The Best Advice Show is Dead. This is Weirdly Helpful! [not-audio_url] [/not-audio_url]

Duration: 12:46
Zak is excited to present Weirdly Helpful, the spiritual successor to The Best Advice Show. On this first episode, Zak talks to artist and therapist, Laura Hawley whose advice from 2020 inspired the new show title. --- T…