The Latest GLP-1 Science on Muscle Loss, Fat Loss, and Weight Regain | Ep 461

The Latest GLP-1 Science on Muscle Loss, Fat Loss, and Weight Regain | Ep 461

Author: Philip Pape, Evidence-Based Nutrition Coach & Fat Loss Expert April 21, 2026 Duration: 31:11
What REALLY happens when you take a GLP-1 drug? Your fat loss, your muscle, your heart, your inflammation, what happens to your weight when you stop, and long-term safety. This episode covers body composition data from the 2026 semaglutide and tirzepatide trials, cardiovascular outcomes from SELECT and SURPASS-CVOT, inflammation findings beyond weight loss, weight regain patterns after stopping, and a 5-part framework to keep muscle on or off the drug after 40. Plus the 2026 safety upda...

Ever feel like you're doing everything right in the gym and kitchen, but the scale and the mirror tell a different story? You're not alone. Wits & Weights | Evidence-Based Fitness & Nutrition for Lifters Over 40 is for those who are past the beginner phase and deep into the grind, yet frustrated by stalled progress. Hosted by Philip Pape, an evidence-based nutrition coach, this podcast cuts through the noise of fitness fads and industry hype. Each episode takes a common, often unquestioned, piece of advice-be it about protein timing, cardio protocols, or specific lifting techniques-and subjects it to a logical, science-informed scrutiny. Philip identifies why these mainstream rules frequently fail, especially for lifters navigating the unique physiological landscape of being over 40, and provides clear, actionable strategies that actually align with how your body works. It’s for the critical thinker who knows that effort deserves intelligent direction. You’ll find practical insights on strength training, sustainable fat loss, and nutrition that prioritizes long-term health and performance without gimmicks. Tune in for a conversation that replaces confusion with clarity and effort with evidence, helping you finally see the results your hard work warrants.
Author: Language: en-us Episodes: 100

Wits & Weights | Evidence-Based Fitness & Nutrition for Lifters Over 40
Podcast Episodes
Why Now Is the PERFECT Time to Build Muscle Over 40 | Ep 393 [not-audio_url] [/not-audio_url]

Duration: 47:33
Get your free Muscle-Building Nutrition Blueprint to optimize your protein intake, calories, and meal timing for maximum muscle growth at any age: https://witsandweights.com/muscle -- Can you still build that much muscle…
7 Tips to Save 200 Hours in the Gym (Without Losing Muscle) | Ep 390 [not-audio_url] [/not-audio_url]

Duration: 30:55
Join Physique University and get the IGNITE 4-Day Time-Saving Workout Program (use code FREEPLAN for a custom nutrition plan when you join) -- Can you cut your gym time by 40 to 50% while still training effectively to bu…
The Myth of Reverse Dieting (Do THIS Instead) | Ep 389 [not-audio_url] [/not-audio_url]

Duration: 30:48
Join the 10-Week Recovery Diet Workshop tomorrow (Tuesday, October 21) at noon Eastern. Get the complete evidence-based protocol for metabolic recovery without reverse dieting. Just $27 includes the full workshop, replay…
Why You Gained 5 Pounds in 3 Days (And Why It's Not Fat) [not-audio_url] [/not-audio_url]

Duration: 5:30
The scale jumps 3–5 pounds after you start eating more and your brain screams, “I knew it, fat gain!” Not so fast. We break down the real reasons behind that early spike and show you how to navigate the first two weeks w…