The Latest GLP-1 Science on Muscle Loss, Fat Loss, and Weight Regain | Ep 461

The Latest GLP-1 Science on Muscle Loss, Fat Loss, and Weight Regain | Ep 461

Author: Philip Pape, Evidence-Based Nutrition Coach & Fat Loss Expert April 21, 2026 Duration: 31:11
What REALLY happens when you take a GLP-1 drug? Your fat loss, your muscle, your heart, your inflammation, what happens to your weight when you stop, and long-term safety. This episode covers body composition data from the 2026 semaglutide and tirzepatide trials, cardiovascular outcomes from SELECT and SURPASS-CVOT, inflammation findings beyond weight loss, weight regain patterns after stopping, and a 5-part framework to keep muscle on or off the drug after 40. Plus the 2026 safety upda...

Ever feel like you're doing everything right in the gym and kitchen, but the scale and the mirror tell a different story? You're not alone. Wits & Weights | Evidence-Based Fitness & Nutrition for Lifters Over 40 is for those who are past the beginner phase and deep into the grind, yet frustrated by stalled progress. Hosted by Philip Pape, an evidence-based nutrition coach, this podcast cuts through the noise of fitness fads and industry hype. Each episode takes a common, often unquestioned, piece of advice-be it about protein timing, cardio protocols, or specific lifting techniques-and subjects it to a logical, science-informed scrutiny. Philip identifies why these mainstream rules frequently fail, especially for lifters navigating the unique physiological landscape of being over 40, and provides clear, actionable strategies that actually align with how your body works. It’s for the critical thinker who knows that effort deserves intelligent direction. You’ll find practical insights on strength training, sustainable fat loss, and nutrition that prioritizes long-term health and performance without gimmicks. Tune in for a conversation that replaces confusion with clarity and effort with evidence, helping you finally see the results your hard work warrants.
Author: Language: en-us Episodes: 100

Wits & Weights | Evidence-Based Fitness & Nutrition for Lifters Over 40
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Midlife Metabolism Myths That Keep You Stuck (and How to Fix Them) [not-audio_url] [/not-audio_url]

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Enjoying the show? Leave a rating (and review) in your podcast app to help more people discover evidence-based fitness information... and let me know if you want more bonus episodes like this one! -- This is my conversat…