The Latest GLP-1 Science on Muscle Loss, Fat Loss, and Weight Regain | Ep 461

The Latest GLP-1 Science on Muscle Loss, Fat Loss, and Weight Regain | Ep 461

Author: Philip Pape | Strength Training & Fat Loss Over 40 April 21, 2026 Duration: 31:11
What REALLY happens when you take a GLP-1 drug? Your fat loss, your muscle, your heart, your inflammation, what happens to your weight when you stop, and long-term safety. This episode covers body composition data from the 2026 semaglutide and tirzepatide trials, cardiovascular outcomes from SELECT and SURPASS-CVOT, inflammation findings beyond weight loss, weight regain patterns after stopping, and a 5-part framework to keep muscle on or off the drug after 40. Plus the 2026 safety upda...

Ever feel like you're doing everything right in the gym and kitchen, but the scale and the mirror tell a different story? You're not alone. Wits & Weights | Evidence-Based Fitness & Nutrition for Lifters Over 40 is for those who are past the beginner phase and deep into the grind, yet frustrated by stalled progress. Hosted by Philip Pape, an evidence-based nutrition coach, this podcast cuts through the noise of fitness fads and industry hype. Each episode takes a common, often unquestioned, piece of advice-be it about protein timing, cardio protocols, or specific lifting techniques-and subjects it to a logical, science-informed scrutiny. Philip identifies why these mainstream rules frequently fail, especially for lifters navigating the unique physiological landscape of being over 40, and provides clear, actionable strategies that actually align with how your body works. It’s for the critical thinker who knows that effort deserves intelligent direction. You’ll find practical insights on strength training, sustainable fat loss, and nutrition that prioritizes long-term health and performance without gimmicks. Tune in for a conversation that replaces confusion with clarity and effort with evidence, helping you finally see the results your hard work warrants.
Author: Language: en-us Episodes: 50

Wits & Weights | Strength Training & Fat Loss Over 40
Podcast Episodes
Sometimes More Is More (The Sedentary Lifter Problem) | Ep 475 [not-audio_url] [/not-audio_url]

Duration: 30:22
You can train hard and still move too little. Learn how daily activity influences fat loss, recovery, metabolic health, and body composition. For a lot of men and women over 40, the highest-leverage change is something e…
The Satiety Diet for Fat Loss After 40 | Ep 473 [not-audio_url] [/not-audio_url]

Duration: 35:11
What if fat loss after 40 didn't require constant hunger? Discover how satiety, protein, food volume, and smart nutrition choices can help you lose fat while protecting muscle. The answer is based on the biology of post-…
Why "Muscle Confusion" Might Actually Work for Hypertrophy | Ep 470 [not-audio_url] [/not-audio_url]

Duration: 25:14
Most lifters dismiss muscle confusion as fitness marketing. But variation can play a role in hypertrophy when it's applied strategically within a strength-training program. We get into how muscles grow, why exercise sele…
The 20-Minute Fix for Menopause Belly Fat | Ep 469 [not-audio_url] [/not-audio_url]

Duration: 26:42
Can you target menopause belly fat? The surprising answer is... yes! It involves how metabolism shifts after 40, why visceral fat behaves differently than subcutaneous fat, and THIS time-efficient form of conditioning th…
The Problem with Most Nutrition Podcasts [not-audio_url] [/not-audio_url]

Duration: 12:46
Why do so many nutrition podcasts leave you more confused than confident, even when the "expert" host sounds so polished and certain? I'm laying out a simple way to filter your podcast feed by prioritizing principles ove…
3 Fat Loss Metrics to Track Before Summer (Beyond the Scale) | Ep 467 [not-audio_url] [/not-audio_url]

Duration: 30:15
The scale only tells part of the story. Learn which metrics better reflect fat loss, body composition, and progress for men and women over 40. The scale can jump 2 to 5 pounds overnight yet you're still losing fat. How i…