The Latest GLP-1 Science on Muscle Loss, Fat Loss, and Weight Regain | Ep 461

The Latest GLP-1 Science on Muscle Loss, Fat Loss, and Weight Regain | Ep 461

Author: Philip Pape, Evidence-Based Nutrition Coach, Strength Training & Fat Loss Expert April 21, 2026 Duration: 32:03
What REALLY happens when you take a GLP-1 drug? Your fat loss, your muscle, your heart, your inflammation, what happens to your weight when you stop, and long-term safety. This episode covers body composition data from the 2026 semaglutide and tirzepatide trials, cardiovascular outcomes from SELECT and SURPASS-CVOT, inflammation findings beyond weight loss, weight regain patterns after stopping, and a 5-part framework to keep muscle on or off the drug after 40. Plus the 2026 safety upda...

Ever feel like you're doing everything right in the gym and kitchen, but the scale and the mirror tell a different story? You're not alone. Wits & Weights | Evidence-Based Fitness & Nutrition for Lifters Over 40 is for those who are past the beginner phase and deep into the grind, yet frustrated by stalled progress. Hosted by Philip Pape, an evidence-based nutrition coach, this podcast cuts through the noise of fitness fads and industry hype. Each episode takes a common, often unquestioned, piece of advice-be it about protein timing, cardio protocols, or specific lifting techniques-and subjects it to a logical, science-informed scrutiny. Philip identifies why these mainstream rules frequently fail, especially for lifters navigating the unique physiological landscape of being over 40, and provides clear, actionable strategies that actually align with how your body works. It’s for the critical thinker who knows that effort deserves intelligent direction. You’ll find practical insights on strength training, sustainable fat loss, and nutrition that prioritizes long-term health and performance without gimmicks. Tune in for a conversation that replaces confusion with clarity and effort with evidence, helping you finally see the results your hard work warrants.
Author: Language: en-us Episodes: 100

Wits & Weights | Evidence-Based Fat Loss & Strength Training Over 40
Podcast Episodes
Is "High Protein" Just Another Fad Diet? | Ep 466 [not-audio_url] [/not-audio_url]

Duration: 27:58
Is high protein just another fad diet? Learn about the 3 criteria that define a fad, how protein performs against each one, the research on lean mass and strength training, the mechanisms behind protein's thermic effect…
Should You Fix Your Diet or Training First? | Ep 465 [not-audio_url] [/not-audio_url]

Duration: 34:12
Should you fix your diet or your training first? You've probably heard that diet is 80% of the results, so nutrition is the obvious place to start. After all, "abs are made in the kitchen" right? The problem is this clai…
Does Every Food Decision Feel Like a Moment of Panic During Fat Loss? [not-audio_url] [/not-audio_url]

Duration: 10:35
Your fat loss plan isn’t broken! The real problem is what happens in the 10 seconds before you order, snack, or say “screw it” after a stressful day. Learn an under-discussed truth about nutrition and fitness progress: t…
Mini-Cuts and Mini-Bulks for Faster Body Recomp After 40 | Ep 463 [not-audio_url] [/not-audio_url]

Duration: 40:16
Bulking, cutting, bulking, cutting. If you've been through that cycle and ended up further from your goal than when you started, there's a reason the yo-yo keeps repeating, especially over 40. Learn about the metabolic a…
5 Ways Intermittent Fasting Backfires for Women Over 40 | Ep 458 [not-audio_url] [/not-audio_url]

Duration: 36:05
Intermittent fasting is still the most popular nutrition advice on the internet. Skip breakfast, shrink your eating window, lose weight. But if you're over 40, this may not give you the results you want. It could even ba…