Dr. Scott Sherr: Methylene Blue for Energy and Mitochondrial Optimization

Dr. Scott Sherr: Methylene Blue for Energy and Mitochondrial Optimization

Author: Abel James August 28, 2025 Duration: 1:09:28
You’ve probably heard the buzz around the mythical and sketchy-sounding synthetic compound known as methylene blue.

How is it that methylene blue went from a 19th-century textile dye to a futuristic, cutting-edge mitochondrial-enhancing compound that turns your tongue blue?

After surviving freak bouts of carbon monoxide poisoning, black mold exposure and chronic lyme disease, methylene blue earned its spot in my bag of tricks many moons ago. Should it be in yours?

With mitochondrial dysfunction affecting a whopping 94% of adults in the U.S., I’d say it’s worth a look.

We’re here with one of the foremost experts and thought leaders integrating intriguing compounds like methylene blue into their practice, Dr. Scott Sherr

While methylene blue is a remarkable tool for healing and performance optimization of the brain and body, it’s not right for everyone. Since methylene blue can interact with certain medications and supplements and we’re still learning about its effects on the microbiome, it’s essential to exercise caution and be intentional about sourcing, dosage, and frequency of use. 

Dr. Scott is here to separate the truth from the hype. 

In this episode, you’re about to discover:
  • How to improve metabolic and mitochondrial function with low-dose methylene blue
  • How combining hyperbaric oxygen therapy and high altitude training with methylene blue further enhance performance
  • How to dose methylene blue strategically
  • And much more…
Find Dr. Scott Sherr and his work at: 
You can also join Substack as a free or paid member for ad-free episodes of this show, to comment on each episode, and to hit me up in the DM’s. Join at abeljames.substack.com. And if you’re feeling generous, write a quick review for the Abel James Show on Apple or Spotify. You rock.

This episode is brought to you by:
Troscriptions - Go to troscriptions.com/WILD or enter WILD at checkout for 10% off your first order.
Crowd Health - Go to JoinCrowdHealth.com and use the code WILD at checkout to get started for as low as $80 per month.
Manukora - Go to MANUKORA.com/WILD to save 31% plus $25 of free gifts.

For over a decade, the Abel James Show has served as a deep and often surprising conversation space where health, business, and human potential intersect. Rather than offering quick fixes, this podcast delves into the nuanced strategies and personal philosophies of top performers across diverse fields. You’ll hear candid, long-form interviews with hundreds of pioneers, from biochemists like Dr. Casey Means and longevity experts like Dr. Mark Hyman to entrepreneurial minds such as Tim Ferriss and James Clear. The discussions naturally explore the practical connections between metabolic health, cognitive performance, and building a meaningful career or business. Launched back in 2012, the show has evolved from its original, playful focus into a broader exploration of what it means to live well and work smart. Tuning in provides a unique blend of actionable science for your body and innovative thinking for your ventures, all framed through Abel’s engaging and curious perspective. Each episode feels like a chance to sit in on a private masterclass, stripping away the hype to examine what truly works for optimizing a modern life.
Author: Language: English Episodes: 100

Abel James Show
Podcast Episodes
Why Trying to Calm Down is Stressing You Out with Dr. Rebecca Heiss [not-audio_url] [/not-audio_url]

Duration: 1:02:55
Feeling a little stressed lately? You're certainly not alone. Counterintuitively, instead of beating yourself up for not being able to calm down and eliminate stress altogether, consciously taking on more stress can actu…
The Art and Science of Sexual Communication with Dr. Nicole McNichols [not-audio_url] [/not-audio_url]

Duration: 1:16:17
Have you ever wondered how much of your happiness comes down to what you were conditioned to believe about sex? Sexual pleasure isn’t a guilty indulgence: science shows that prioritizing pleasure can build resilience, im…
Henry Abbott: Why Star Athletes Are Getting Injured More Than Ever [not-audio_url] [/not-audio_url]

Duration: 1:05:39
A modern mystery haunts professional sports: Why are today's star athletes—who are bigger, faster, and stronger than ever—getting injured at such catastrophic rates?The glory days when all-stars like Cal Ripkin Jr. playe…
Donnie Yance: Why Microdosing is More Effective Than Macrodosing [not-audio_url] [/not-audio_url]

Duration: 1:15:31
Is microdosing more effective than macrodosing? While heavy-handed megadoses of synthetic pharmaceuticals attempt to dominate a single biochemical pathway, microdoses of synergistic botanticals can stimulate the body to…
Why Training for Resilience Could Save Your Life [not-audio_url] [/not-audio_url]

Duration: 1:46:06
As soon as you think you have it all figured out, absolutely everything can change in an instant. What do you do when out of nowhere, life hands you a serious injury or diagnosis? In this episode, I'll be sharing hard‑wo…