RHR: Why Microglia Are the Key to Brain Health, with Dr. David Perlmutter

RHR: Why Microglia Are the Key to Brain Health, with Dr. David Perlmutter

Author: Chris Kresser August 11, 2026 Duration: 56:14

In this episode of Revolution Health Radio, Chris Kresser sits down with renowned neurologist and bestselling author Dr. David Perlmutter to discuss the emerging science of microglia—the brain's immune cells—and why they may hold the key to preventing cognitive decline and Alzheimer's disease. Drawing from his new book, Brain Defenders, Dr. Perlmutter explains how lifestyle factors such as nutrition, exercise, sleep, metabolic health, and gut health influence whether microglia protect the brain or contribute to chronic inflammation and neurodegeneration. Together, they challenge the outdated notion that dementia is largely predetermined by genetics, highlighting growing evidence that proactive lifestyle interventions can preserve—and even improve—brain function throughout life.

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Tired of health advice that feels one-size-fits-all or contradicts what you heard last week? Revolution Health Radio cuts through the noise with a different approach. Hosted by health detective Chris Kresser, this podcast digs into the often overlooked root causes of modern chronic conditions, moving beyond just treating symptoms. Each episode is a deep, evidence-informed conversation that challenges conventional wisdom on diet, fitness, and wellness. You’ll hear detailed explorations on topics like metabolic health, gut microbiome science, and sustainable fitness practices, all framed around actionable strategies for real life. Kresser translates complex research into practical steps, empowering you to make informed decisions about your own well-being. Rather than offering quick fixes, this podcast builds a foundational understanding of how the body works, aiming for lasting vitality. It’s for anyone who feels let down by mainstream narratives and is curious about the nuanced, sometimes alternative, paths to preventing illness and optimizing health. Tune in for thoughtful dialogues that equip you with the knowledge to take true ownership of your health journey.
Author: Language: en-us Episodes: 43

Revolution Health Radio
Podcast Episodes
RHR: Can You Reverse Your Biological Age? [not-audio_url] [/not-audio_url]

Duration: 23:54
In this episode of Revolution Health Radio, Chris Kresser explores what biological age really means and examines the research behind today's most popular longevity claims. He explains how epigenetic clocks and DNA methyl…
RHR: Your Mouth is Talking To Your Brain—And You Should Be Listening [not-audio_url] [/not-audio_url]

Duration: 25:08
What if one of the most overlooked risk factors for cognitive decline isn’t in the brain—but in the mouth? In this episode of Revolution Health Radio, Chris Kresser explores the emerging science linking oral health to br…
RHR: Revisiting the Gut-Immune Axis [not-audio_url] [/not-audio_url]

Duration: 26:11
The gut-immune axis is one of the most important and most overlooked systems in human health. In this episode of Revolution Health Radio, Chris explains how the gut microbiome, intestinal barrier, and immune system work…
RHR: Shaking Up the Salt Myth [not-audio_url] [/not-audio_url]

Duration: 20:52
For decades, public health guidelines have warned that reducing sodium intake is essential for preventing high blood pressure and cardiovascular disease. But a closer look at the scientific evidence reveals a far more co…
RHR: Mouth Taping: Beyond the Hype—What the Science Really Says [not-audio_url] [/not-audio_url]

Duration: 17:27
In this episode of Revolution Health Radio, Chris Kresser explores the viral trend of mouth taping and explains why the reality is more complex than the hype. While nasal breathing offers clear physiological advantages s…