RHR: Why Microglia Are the Key to Brain Health, with Dr. David Perlmutter

RHR: Why Microglia Are the Key to Brain Health, with Dr. David Perlmutter

Author: Chris Kresser August 11, 2026 Duration: 56:14

In this episode of Revolution Health Radio, Chris Kresser sits down with renowned neurologist and bestselling author Dr. David Perlmutter to discuss the emerging science of microglia—the brain's immune cells—and why they may hold the key to preventing cognitive decline and Alzheimer's disease. Drawing from his new book, Brain Defenders, Dr. Perlmutter explains how lifestyle factors such as nutrition, exercise, sleep, metabolic health, and gut health influence whether microglia protect the brain or contribute to chronic inflammation and neurodegeneration. Together, they challenge the outdated notion that dementia is largely predetermined by genetics, highlighting growing evidence that proactive lifestyle interventions can preserve—and even improve—brain function throughout life.

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Tired of health advice that feels one-size-fits-all or contradicts what you heard last week? Revolution Health Radio cuts through the noise with a different approach. Hosted by health detective Chris Kresser, this podcast digs into the often overlooked root causes of modern chronic conditions, moving beyond just treating symptoms. Each episode is a deep, evidence-informed conversation that challenges conventional wisdom on diet, fitness, and wellness. You’ll hear detailed explorations on topics like metabolic health, gut microbiome science, and sustainable fitness practices, all framed around actionable strategies for real life. Kresser translates complex research into practical steps, empowering you to make informed decisions about your own well-being. Rather than offering quick fixes, this podcast builds a foundational understanding of how the body works, aiming for lasting vitality. It’s for anyone who feels let down by mainstream narratives and is curious about the nuanced, sometimes alternative, paths to preventing illness and optimizing health. Tune in for thoughtful dialogues that equip you with the knowledge to take true ownership of your health journey.
Author: Language: en-us Episodes: 43

Revolution Health Radio
Podcast Episodes
RHR: Exploring Peak Health and Fitness, with Mark Sisson [not-audio_url] [/not-audio_url]

Duration: 54:07
In this episode of Revolution Health Radio, Chris Kresser talks with Mark Sisson, author of Born to Walk and renowned figure in the ancestral health space, about rethinking our approach to fitness. They challenge the con…
RHR: Gut Health 3.0- The Power of Polyphenols and Postbiotics [not-audio_url] [/not-audio_url]

Duration: 45:29
In this episode of Revolution Health Radio, Chris Kresser unveils the world of Gut Health 3.0, a comprehensive approach that goes far beyond traditional probiotic supplementation. Drawing on the latest scientific researc…
RHR: Revolutionizing Cancer Treatment, with Dr. Chris Apfel [not-audio_url] [/not-audio_url]

Duration: 42:17
In this episode of Revolution Health Radio, Chris sits down with Dr. Chris Apfel, founder of SageMedic, to discuss innovations in cancer treatment. Dr. Apfel shares how his personal experiences with cancer in his family…
RHR: Beyond Biohacking to Metabolic Mastery, with Dr. Casey Means [not-audio_url] [/not-audio_url]

Duration: 1:01:49
In this episode of Revolution Health Radio, Chris is joined by physician Dr. Casey Means, co-founder of the health tech company Levels, to discuss her new book, Good Energy, which explores the crucial role of metabolic h…
RHR: Integrative Approaches to Childhood Cancer, with Dagmara Beine [not-audio_url] [/not-audio_url]

Duration: 56:22
In this episode of Revolution Health Radio, Chris Kresser speaks with Dagmara Beine, an expert in integrative pediatric oncology. Dagmara shares her personal journey from emergency medicine to holistic cancer care follow…
RHR: The Science of Longevity and Performance, with Kien Vuu [not-audio_url] [/not-audio_url]

Duration: 50:36
In this episode of Revolution Health Radio, Chris speaks with Dr. Kien Vuu, who shares his journey from a medical doctor to a proponent of integrating science with spirituality for holistic health. They discuss Dr. Vuu's…