RHR: Why Microglia Are the Key to Brain Health, with Dr. David Perlmutter

RHR: Why Microglia Are the Key to Brain Health, with Dr. David Perlmutter

Author: Chris Kresser August 11, 2026 Duration: 56:14

In this episode of Revolution Health Radio, Chris Kresser sits down with renowned neurologist and bestselling author Dr. David Perlmutter to discuss the emerging science of microglia—the brain's immune cells—and why they may hold the key to preventing cognitive decline and Alzheimer's disease. Drawing from his new book, Brain Defenders, Dr. Perlmutter explains how lifestyle factors such as nutrition, exercise, sleep, metabolic health, and gut health influence whether microglia protect the brain or contribute to chronic inflammation and neurodegeneration. Together, they challenge the outdated notion that dementia is largely predetermined by genetics, highlighting growing evidence that proactive lifestyle interventions can preserve—and even improve—brain function throughout life.

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Tired of health advice that feels one-size-fits-all or contradicts what you heard last week? Revolution Health Radio cuts through the noise with a different approach. Hosted by health detective Chris Kresser, this podcast digs into the often overlooked root causes of modern chronic conditions, moving beyond just treating symptoms. Each episode is a deep, evidence-informed conversation that challenges conventional wisdom on diet, fitness, and wellness. You’ll hear detailed explorations on topics like metabolic health, gut microbiome science, and sustainable fitness practices, all framed around actionable strategies for real life. Kresser translates complex research into practical steps, empowering you to make informed decisions about your own well-being. Rather than offering quick fixes, this podcast builds a foundational understanding of how the body works, aiming for lasting vitality. It’s for anyone who feels let down by mainstream narratives and is curious about the nuanced, sometimes alternative, paths to preventing illness and optimizing health. Tune in for thoughtful dialogues that equip you with the knowledge to take true ownership of your health journey.
Author: Language: en-us Episodes: 43

Revolution Health Radio
Podcast Episodes
RHR: The Longevity Trap: Why Chasing Anti-Aging May Be Aging You [not-audio_url] [/not-audio_url]

Duration: 15:58
In this episode, Chris explains why obsession with anti-aging hacks may actually undermine our long-term health. He examines the common longevity traps people fall into, which foundational habits truly extend lifespan an…
RHR: The Science Behind Oral Inflammation, with Dr. William Levine [not-audio_url] [/not-audio_url]

Duration: 41:39
In this episode of Revolution Health Radio, Chris welcomes board-certified periodontist Dr. William Levine to discuss the overlooked role of gum health in systemic disease. They unpack how oral bacteria and chronic infla…
RHR: The Nourishment Table, with Frederic Leroy [not-audio_url] [/not-audio_url]

Duration: 1:05:34
In this episode of Revolution Health Radio, Chris Kresser welcomes food scientist and advocate for regenerative agriculture Dr. Frederic Leroy to discuss his groundbreaking work on the Nourishment Table, a new framework…
RHR: Everything You Need to Know About Collagen [not-audio_url] [/not-audio_url]

Duration: 1:07:35
In this episode of Revolution Health Radio, Chris Kresser dives deep into the fascinating world of collagen, the most abundant protein in the human body. He explores collagen's wide-ranging benefits—from supporting vibra…