The Future of Medicine Is Energy: Dr. Martin Picard Explains
Author: Dr. Mark Hyman
November 19, 2025
Duration: 1:48:43
I’ve seen so many patients struggle with fatigue, brain fog, and burnout, and this conversation gave me a new way of thinking about why that happens and how to approach it.
On this episode of The Dr. Hyman Show, I’m joined by Dr. Martin Picard, a Columbia scientist studying how energy flows through the body, and what that flow means for how we think, feel, and age. We touch on a simple idea that could reframe the way you understand your own energy, and how your daily choices influence it over time. Catch the full conversation on YouTube or listen wherever you get your podcasts.
We uncover:
• Why your energy can feel “off” even when labs look normal
• What mitochondria communicate beyond just ATP production
• How stress, recovery, and sleep shift your cellular energy capacity
• Why individuality matters more than group averages in real life health outcomes
• The simple daily choices that build or drain metabolic resilience over time
At the end of the day, energy is the foundation of how we show up in our lives, and we can influence it more than we think.
Resources on the blog:
• Phenomics and the Energy Resistance Principle
View Show Notes From This Episode
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(0:00) Intro: Martin Picard
(1:56) Metabolism, Mental Health & Functional Med
(6:00) Mitochondria’s Role in Health
(14:15) Food, Diet & Lifestyle Impacts
(16:31) Understanding Mitochondrial Functions
(20:30) Communication & Energy Transfer
(24:22) Dr. Hyman’s Mitochondrial Story
(26:23) The Energy Resistance Principle
(31:08) Energy Budgets, Compensation & Exercise
(38:47) Applying Energy Resistance
(41:08) Fatigue, Sleep & Mitochondria
(43:02) Health Implications
(47:38) Measuring Function & Biomarkers
(49:22) Dysfunction & Health Impact
(55:23) Inflammation & Cytokines
(1:00:00) Exercise & Flow State
(1:01:21) Muscle Fatigue & Heart Pain
(1:03:20) Conditions & Mitochondrial Health
(1:04:08) Rest & Individualized Treatment
(1:07:39) Clinical Assessments
(1:10:00) Stress Testing & Energy Flow
(1:13:09) Lifestyle Interventions
(1:17:24) Mitoception & Awareness
(1:20:08) Future Clinical Practices
(1:21:48) Keto Diet & Mental Health
(1:27:03) Energy Conservation in Illness
(1:32:08) Stress, Resilience & Sleep
