We talk a lot about hormones in midlife, hot flashes, weight gain, sleep issues, low libido. But one of the biggest complaints I hear from women is actually about their brain. The brain fog. The anxiety that comes out of nowhere. The flat motivation. The unpredictable sleep. The feeling that you just do not feel like yourself anymore. And for a lot of women, that is the part that feels the most unsettling.
In this episode, I sit down with Dr. Scott Sherr to go much deeper into what may actually be happening underneath those symptoms. We talk about mitochondria, brain energy, neurotransmitters, methylene blue, nitric oxide, GABA, glutamate, and even nicotine, and how all of these may play a role in the way the midlife brain feels and functions.
This is one of those conversations that helps connect the dots between hormones and everything else that is happening in the brain and nervous system during this transition.
If you have been feeling mentally flat, overstimulated, exhausted, or like your brain has changed in ways no one can fully explain, this conversation is going to open up a whole new lens on what may be going on.
In this episode, we cover:
- Why brain fog is such a common midlife complaint
- What mitochondria actually are and why they matter for brain energy
- How estrogen loss may contribute to mitochondrial dysfunction
- How methylene blue may support mitochondria, energy production, and mental clarity
- The difference between low-dose and high-dose methylene blue use
- The truth about methylene blue and nitric oxide
- Why GABA, glutamate, progesterone, magnesium, and B6 matter for the midlife brain
- How stress and sympathetic overload affect mood, sleep, and focus
- Why nicotine is being explored for cognition, brain inflammation, and vagus nerve support
- Why HRT may help, but may not be the whole story for every woman
Who this episode is for
This episode is for women in perimenopause and menopause who are dealing with brain fog, anxiety, fatigue, poor motivation, sleep disruption, feeling overstimulated, or simply not feeling like themselves anymore. It is especially for women who want to understand what may be happening beyond hormones alone and are curious about the role of mitochondrial health, brain energy, and neurotransmitters in midlife symptoms.
Dr. Sherr is a board-certified internal medicine physician and a specialist in Hyperbaric Oxygen Therapy. He's the COO of Troscriptions, a company developing physician-formulated buccal troches designed to support things like energy, focus, sleep, and stress resilience using compounds like methylene blue and other novel ingredients.
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Are you in perimenopause or postmenopause and struggling with symptoms—but not getting the support you deserve?
At Midlife Solutions, we specialize in hormone optimization for women in midlife. Our all-female clinical team offers telehealth care across all 50 U.S. states, with the ability to prescribe bioidentical estrogen, progesterone, testosterone, and thyroid medication.
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Your host:
Karen Martel
Certified Hormone Specialist, Transformational Nutrition Coach, & Weight Loss Expert
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