The Link Between the Gut Microbiome and Our Immune System with Dr. Jeffrey Bland

The Link Between the Gut Microbiome and Our Immune System with Dr. Jeffrey Bland

Author: JJ Virgin February 18, 2026 Duration: 50:22
How do ultra-processed foods change the way your genes behave? In this episode, I talk with my longtime friend and mentor, Dr. Jeffrey Bland, about why ultra-processed foods may be the most dangerous health experiment humans have ever run. We explored how food acts as information—shaping gene expression, immune health, and even how full or satisfied you feel. Dr. Bland, often called the father of functional medicine, brings decades of insight into how modern food systems are quietly rewriting our biology. Dr. Jeffrey Bland is known as the father of functional medicine and has spent over five decades studying how food, lifestyle, and biology shape human health. He’s a prolific educator, researcher, and founder behind multiple institutes, including Big Bold Health, dedicated to personalized and preventive medicine. What you’ll learn: (02:44) Why ultra-processed foods may be the biggest driver of modern chronic disease. (04:32) How food functions as biological information that influences gene expression. (06:49) Why life expectancy is declining despite advances in modern medicine. (09:22) How ultra-processed foods disrupt the gut microbiome and immune system. (17:38) What distinguishes healthy gut bacteria from harmful microbial patterns. (24:39) Why poor satiety from processed foods fuels weight gain and GLP-1 drug use. (28:29) How bitter compounds in natural foods naturally stimulate satiety hormones. (39:39) One simple mindset shift that can immediately improve food choices and health. Love the podcast? Here’s what to do: Subscribe to the podcast. Leave a review. Text a screenshot to me at 813-565-2627 and wait for a personal reply because your voice is so important to me. Want to listen to the show completely ad-free? Go to http://subscribetojj.com Click “TRY FREE” and start your ad-free journey today! When you’re ready, enjoy the VIP experience for just $4.99 per month or $49.99 per year (save 17%!) Full show notes (including all links mentioned): https://jjvirgin.com/bold → Fatty15 | Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness - especially as you age. You can get an additional 15% off their 90-day subscription Starter Kit by going to https://fatty15.com/VIRGINWELLNESS and using code VIRGINWELLNESS at checkout. Learn more about your ad choices. Visit megaphone.fm/adchoices

Midlife isn't a crisis; it's a catalyst. On Well Beyond 40, JJ Virgin guides a conversation about rewriting the narrative of aging for women, moving from simply coping to truly thriving. This isn't about chasing youth, but about building a foundation of strength and vitality that makes the coming decades the most rewarding yet. Each episode feels like a direct, practical talk with a trusted expert who cuts through the noise. You'll hear actionable strategies rooted in science, focusing on how nutrition, movement, and mindset intersect uniquely during this life stage. JJ translates complex research into clear steps for refueling your body, managing energy, and cultivating a sense of purpose that goes far beyond the scale. The Well Beyond 40 podcast operates on the principle that knowing *why* something works is just as important as knowing *what* to do. Listeners are invited into a space where questions about metabolic shifts, hormonal balance, sustainable fitness, and intentional beauty are met with evidence-based answers and genuine empathy. It’s a resource for any woman ready to move past generic advice and discover what it means to age with power, confidence, and joy on her own terms. Tune in to reframe your approach and build a life that feels truly well-lived.
Author: Language: English Episodes: 100

Well Beyond 40
Podcast Episodes
Heal Your Gut and Master Menopause with Cynthia Thurlow [not-audio_url] [/not-audio_url]

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What if the key to a better night's sleep isn't just a pill, but better gut health? I am so thrilled to welcome my dear friend Cynthia Thurlow, a brilliant nurse practitioner and expert in intermittent fasting, back to t…
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Dr. Jason Fung Explains Why You Are Always Hungry [not-audio_url] [/not-audio_url]

Duration: 49:17
Are you tired of being told that your weight gain is simply a result of a lack of willpower? In this episode, I’m thrilled to welcome back my friend and world-renowned kidney specialist, Dr. Jason Fung, to dive deep into…
Cravings After 40 Are Not a Discipline Problem [not-audio_url] [/not-audio_url]

Duration: 15:22
What if your cravings have nothing to do with discipline? I want you to stop blaming a lack of discipline for your midlife cravings and understand that your body runs on chemistry, not willpower. In this episode, I break…
Mastering Your Internal Symphony [not-audio_url] [/not-audio_url]

Duration: 12:41
Deanna Minich is a nutrition scientist and functional medicine expert who specializes in how food, light, and lifestyle impact whole-body health. She’s known for blending science with practical strategies to help people…
Why Lifting Weights is the Secret to Fat Loss [not-audio_url] [/not-audio_url]

Duration: 23:31
Are you losing muscle instead of fat by over-prioritizing cardio? I'm here to tell you that the common advice to lose weight before lifting is biologically backwards and keeping you frustrated and stuck. In this episode,…
Why Coffee is a Health Superfood with Andrew Salisbury [not-audio_url] [/not-audio_url]

Duration: 42:09
Could your "guilty pleasure" actually be the best thing for your liver health? I’m diving deep into my favorite food group today with Andrew Salisbury, the founder of Purity Coffee, to reveal why your morning brew is act…
What Collagen Actually Does After 30 [not-audio_url] [/not-audio_url]

Duration: 20:24
Are you using collagen incorrectly as a protein replacement? Collagen is one of the most misunderstood supplements in the health world, and I’m breaking down the real science behind it. I explain what collagen actually d…