The Link Between the Gut Microbiome and Our Immune System with Dr. Jeffrey Bland

The Link Between the Gut Microbiome and Our Immune System with Dr. Jeffrey Bland

Author: JJ Virgin February 18, 2026 Duration: 50:22
How do ultra-processed foods change the way your genes behave? In this episode, I talk with my longtime friend and mentor, Dr. Jeffrey Bland, about why ultra-processed foods may be the most dangerous health experiment humans have ever run. We explored how food acts as information—shaping gene expression, immune health, and even how full or satisfied you feel. Dr. Bland, often called the father of functional medicine, brings decades of insight into how modern food systems are quietly rewriting our biology. Dr. Jeffrey Bland is known as the father of functional medicine and has spent over five decades studying how food, lifestyle, and biology shape human health. He’s a prolific educator, researcher, and founder behind multiple institutes, including Big Bold Health, dedicated to personalized and preventive medicine. What you’ll learn: (02:44) Why ultra-processed foods may be the biggest driver of modern chronic disease. (04:32) How food functions as biological information that influences gene expression. (06:49) Why life expectancy is declining despite advances in modern medicine. (09:22) How ultra-processed foods disrupt the gut microbiome and immune system. (17:38) What distinguishes healthy gut bacteria from harmful microbial patterns. (24:39) Why poor satiety from processed foods fuels weight gain and GLP-1 drug use. (28:29) How bitter compounds in natural foods naturally stimulate satiety hormones. (39:39) One simple mindset shift that can immediately improve food choices and health. Love the podcast? Here’s what to do: Subscribe to the podcast. Leave a review. Text a screenshot to me at 813-565-2627 and wait for a personal reply because your voice is so important to me. Want to listen to the show completely ad-free? Go to http://subscribetojj.com Click “TRY FREE” and start your ad-free journey today! When you’re ready, enjoy the VIP experience for just $4.99 per month or $49.99 per year (save 17%!) Full show notes (including all links mentioned): https://jjvirgin.com/bold → Fatty15 | Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness - especially as you age. You can get an additional 15% off their 90-day subscription Starter Kit by going to https://fatty15.com/VIRGINWELLNESS and using code VIRGINWELLNESS at checkout. Learn more about your ad choices. Visit megaphone.fm/adchoices

Midlife isn't a crisis; it's a catalyst. On Well Beyond 40, JJ Virgin guides a conversation about rewriting the narrative of aging for women, moving from simply coping to truly thriving. This isn't about chasing youth, but about building a foundation of strength and vitality that makes the coming decades the most rewarding yet. Each episode feels like a direct, practical talk with a trusted expert who cuts through the noise. You'll hear actionable strategies rooted in science, focusing on how nutrition, movement, and mindset intersect uniquely during this life stage. JJ translates complex research into clear steps for refueling your body, managing energy, and cultivating a sense of purpose that goes far beyond the scale. The Well Beyond 40 podcast operates on the principle that knowing *why* something works is just as important as knowing *what* to do. Listeners are invited into a space where questions about metabolic shifts, hormonal balance, sustainable fitness, and intentional beauty are met with evidence-based answers and genuine empathy. It’s a resource for any woman ready to move past generic advice and discover what it means to age with power, confidence, and joy on her own terms. Tune in to reframe your approach and build a life that feels truly well-lived.
Author: Language: English Episodes: 100

Well Beyond 40
Podcast Episodes
6 Free Or Low-Cost Biohacks That Boost Metabolism and Longevity [not-audio_url] [/not-audio_url]

Duration: 19:25
How can free or inexpensive daily habits improve your metabolism and longevity? In this episode, I break down why you don’t need expensive gadgets or a massive biohacking budget to age powerfully. I walk you through six…
Unpacking GLP-1s: A New Approach to Weight Health with Ashley Koff [not-audio_url] [/not-audio_url]

Duration: 46:35
What if the goal wasn't just to lose weight, but to achieve a balanced "weight health ecosystem"? In this episode, I speak with Ashley Koff about how ultra-processed foods, under-fueling, and disrupted hormones have shap…
FODMAPs Explained: Why Healthy Foods Suddenly Hurt [not-audio_url] [/not-audio_url]

Duration: 19:57
Why do healthy foods suddenly cause bloating and pain? In this episode, I share how one of the most stressful seasons of my life completely changed my gut and forced me to rethink foods I’d eaten for years without issue.…
Sarcopenia After 40: Dr. William Evans on Muscle and Aging [not-audio_url] [/not-audio_url]

Duration: 58:41
In your later decades, how can strength training reverse muscle loss? In this episode, I spoke with Dr. William Evans, the scientist who first described sarcopenia, to unpack why muscle loss—not aging itself—is the bigge…
Exercise Myths That Sabotage Metabolism After 40 [not-audio_url] [/not-audio_url]

Duration: 20:49
How can outdated workout myths keep you exhausted and inflamed? I’m calling out the exercise myths that once worked for me—but quietly stopped serving women after 40. In this episode, I break down why harder workouts, fa…
Understanding How Your Brain ACTUALLY Works with Bizzie Gold [not-audio_url] [/not-audio_url]

Duration: 1:02:20
Are the invisible emotional patterns from your past the real reason you're stuck in your health or relationships? In this episode, Bizzie Gold and I explore why so many of us stay stuck in patterns that no longer serve u…
My Facelift Story: What Went Wrong and Right [not-audio_url] [/not-audio_url]

Duration: 26:35
What questions should you ask a surgeon before committing to a facelift? In this episode, I’m sharing the full, unfiltered story of my facelift, including what went wrong, what saved my recovery, and why I’d still make t…
The Real Goal After 40 Is Building Muscle, Strength & Power [not-audio_url] [/not-audio_url]

Duration: 25:40
Why does cardio stop working for fat loss after 40? Also, what types of exercise best protect strength and independence as you age? In this episode, I break down why the goal of exercise after 40 is no longer burning cal…