The Link Between the Gut Microbiome and Our Immune System with Dr. Jeffrey Bland

The Link Between the Gut Microbiome and Our Immune System with Dr. Jeffrey Bland

Author: JJ Virgin February 18, 2026 Duration: 50:22
How do ultra-processed foods change the way your genes behave? In this episode, I talk with my longtime friend and mentor, Dr. Jeffrey Bland, about why ultra-processed foods may be the most dangerous health experiment humans have ever run. We explored how food acts as information—shaping gene expression, immune health, and even how full or satisfied you feel. Dr. Bland, often called the father of functional medicine, brings decades of insight into how modern food systems are quietly rewriting our biology. Dr. Jeffrey Bland is known as the father of functional medicine and has spent over five decades studying how food, lifestyle, and biology shape human health. He’s a prolific educator, researcher, and founder behind multiple institutes, including Big Bold Health, dedicated to personalized and preventive medicine. What you’ll learn: (02:44) Why ultra-processed foods may be the biggest driver of modern chronic disease. (04:32) How food functions as biological information that influences gene expression. (06:49) Why life expectancy is declining despite advances in modern medicine. (09:22) How ultra-processed foods disrupt the gut microbiome and immune system. (17:38) What distinguishes healthy gut bacteria from harmful microbial patterns. (24:39) Why poor satiety from processed foods fuels weight gain and GLP-1 drug use. (28:29) How bitter compounds in natural foods naturally stimulate satiety hormones. (39:39) One simple mindset shift that can immediately improve food choices and health. Love the podcast? Here’s what to do: Subscribe to the podcast. Leave a review. Text a screenshot to me at 813-565-2627 and wait for a personal reply because your voice is so important to me. Want to listen to the show completely ad-free? Go to http://subscribetojj.com Click “TRY FREE” and start your ad-free journey today! When you’re ready, enjoy the VIP experience for just $4.99 per month or $49.99 per year (save 17%!) Full show notes (including all links mentioned): https://jjvirgin.com/bold → Fatty15 | Fatty15 is on a mission to optimize your C15 levels to help support your long-term health and wellness - especially as you age. You can get an additional 15% off their 90-day subscription Starter Kit by going to https://fatty15.com/VIRGINWELLNESS and using code VIRGINWELLNESS at checkout. Learn more about your ad choices. Visit megaphone.fm/adchoices

Midlife isn't a crisis; it's a catalyst. On Well Beyond 40, JJ Virgin guides a conversation about rewriting the narrative of aging for women, moving from simply coping to truly thriving. This isn't about chasing youth, but about building a foundation of strength and vitality that makes the coming decades the most rewarding yet. Each episode feels like a direct, practical talk with a trusted expert who cuts through the noise. You'll hear actionable strategies rooted in science, focusing on how nutrition, movement, and mindset intersect uniquely during this life stage. JJ translates complex research into clear steps for refueling your body, managing energy, and cultivating a sense of purpose that goes far beyond the scale. The Well Beyond 40 podcast operates on the principle that knowing *why* something works is just as important as knowing *what* to do. Listeners are invited into a space where questions about metabolic shifts, hormonal balance, sustainable fitness, and intentional beauty are met with evidence-based answers and genuine empathy. It’s a resource for any woman ready to move past generic advice and discover what it means to age with power, confidence, and joy on her own terms. Tune in to reframe your approach and build a life that feels truly well-lived.
Author: Language: English Episodes: 100

Well Beyond 40
Podcast Episodes
Animal vs. Plant Protein [not-audio_url] [/not-audio_url]

Duration: 20:03
It’s not tofu versus steak. It’s both. There’s a battle raging in the health world over plant vs. animal protein—but the truth is, this isn’t an either/or game. It’s about combining the best of both to fuel muscle, metab…
The Ultimate Creatine Guide for Women Over 40 [not-audio_url] [/not-audio_url]

Duration: 28:38
Download my Ultimate Creatine Guide for Women before listening so you can read along and get the most out of the episode. You know that feeling when you discover something that completely changes your perspective on heal…
The Truth About Breakfast and Fat Loss for Women Over 40 [not-audio_url] [/not-audio_url]

Duration: 20:25
The intermittent fasting craze has left so many of us confused about whether we should eat breakfast or skip it entirely. I've watched women swing from one extreme to the other - from grabbing a muffin and latte on the r…
The Biology of Trauma with Dr. Aimie Apigian [not-audio_url] [/not-audio_url]

Duration: 49:32
"Trauma becomes a burden that the body carries…and it's up to you to decide, do I still want to carry this or do I want to put it down?" - Dr. Aimie Apigian You know how some women say they sailed through menopause like…
Why I'm Breaking Up with My Bathroom Scale (And You Should Too) [not-audio_url] [/not-audio_url]

Duration: 22:33
After decades in the health industry, I'm on a mission to get rid of traditional scales. Here's why: We've been focusing on the wrong metric for far too long, and it's doing real metabolic damage, especially to women ove…
Hidden Food Additives Sabotaging Women Over 40 with Courtney Swan [not-audio_url] [/not-audio_url]

Duration: 1:12:06
"We have allowed about 10,000 additives into our food supply. In the EU, they allow around 300 to 400 additives depending on what country you're looking at. 300 to 400 versus 10,000 is a large leap." - Courtney Swan The…